Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Eosinophil peroxidase

The EPX gene encodes a peroxidase wich is predominantly expressed in eosinophils. An association with allergic food reactions is discussed.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Eosinophil peroxidase deficiency
EPX

References:

1.

Sakamaki K et. al. (1989) Molecular cloning and characterization of a chromosomal gene for human eosinophil peroxidase.

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2.

Romano M et. al. (1994) Hereditary eosinophil peroxidase deficiency: immunochemical and spectroscopic studies and evidence for a compound heterozygosity of the defect.

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3.

Sakamaki K et. al. (2000) The eosinophil peroxidase gene forms a cluster with the genes for myeloperoxidase and lactoperoxidase on human chromosome 17.

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4.

Nakagawa T et. al. (2001) Eosinophilic peroxidase deficiency: Identification of a point mutation (D648N) and prediction of structural changes.

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Update: Sept. 26, 2018