Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Left-right determination factor 2

The LEFTY2 gene encodes a ligand protein to TGF-beta. It is involved in left-right asymmetry development of heart and lung in particular. Mutations cause autosomal dominant Left-right axis malformations.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Left-right axis malformations
LEFTY2

References:

1.

Meno C et al. (1996) Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos.

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2.

Kothapalli R et al. (1997) Detection of ebaf, a novel human gene of the transforming growth factor beta superfamily association of gene expression with endometrial bleeding.

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3.

Meno C et al. (1997) Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos.

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4.

Kosaki K et al. (1999) Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development.

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5.

Meno C et al. (1999) Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation.

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6.

Burdine RD et al. (2000) Conserved and divergent mechanisms in left-right axis formation.

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7.

Tabibzadeh S et al. (2000) Dysregulated expression of ebaf, a novel molecular defect in the endometria of patients with infertility.

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8.

Meno C et al. (2001) Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2.

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9.

OMIM.ORG article

Omim 601877 [^]
10.

Orphanet article

Orphanet ID 168165 [^]
11.

NCBI article

NCBI 7044 [^]
12.

Wikipedia article

Wikipedia EN (LEFTY2) [^]
Update: April 29, 2019