Left-right determination factor 2
The LEFTY2 gene encodes a ligand protein to TGF-beta. It is involved in left-right asymmetry development of heart and lung in particular. Mutations cause autosomal dominant Left-right axis malformations.
Genetests:
Related Diseases:
References:
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Meno C et al. (1996) Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos.
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Kothapalli R et al. (1997) Detection of ebaf, a novel human gene of the transforming growth factor beta superfamily association of gene expression with endometrial bleeding.
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Meno C et al. (1997) Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos.
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Kosaki K et al. (1999) Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development.
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Meno C et al. (1999) Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation.
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Burdine RD et al. (2000) Conserved and divergent mechanisms in left-right axis formation.
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Tabibzadeh S et al. (2000) Dysregulated expression of ebaf, a novel molecular defect in the endometria of patients with infertility.
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Meno C et al. (2001) Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2.
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OMIM.ORG article
Omim 601877
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Orphanet article
Orphanet ID 168165
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NCBI article
NCBI 7044
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12. |
Wikipedia article
Wikipedia EN (LEFTY2)
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Update: Aug. 14, 2020