Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Tribbles homolog 1

The TRIB1 gene encodes a regulator of the carbohydrate metabolism with implications on lipid metabolism. Therefore in genome-wide association studies this locus is found connected with lipid disorders and coronary artery disease. The exact mechanism by which this protein exerts its effect is yet unknown.

Genetests:

Clinic Method Carrier testing
Turnaround 5
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25
Specimen type genomic DNA

Related Diseases:

Disturbed regulators of lipid and carbohydrate metabolism
GCKR
GPD1
MLXIPL
TRIB1

References:

1.

Cefalù AB et. al. () Identification of a novel LMF1 nonsense mutation responsible for severe hypertriglyceridemia by targeted next-generation sequencing.

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2.

Wilkin F et. al. (1997) Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells.

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3.

Wu M et. al. (2003) SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription.

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4.

Storlazzi CT et. al. (2004) Identification of a commonly amplified 4.3 Mb region with overexpression of C8FW, but not MYC in MYC-containing double minutes in myeloid malignancies.

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5.

Kiss-Toth E et. al. (2004) Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.

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6.

Satoh T et. al. (2013) Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages.

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7.

Yoshida A et. al. (2013) COP1 targets C/EBPα for degradation and induces acute myeloid leukemia via Trib1.

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8.

Hegedus Z et. al. (2006) Tribbles: novel regulators of cell function; evolutionary aspects.

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9.

Bauer RC et. al. (2011) Functional validation of new pathways in lipoprotein metabolism identified by human genetics.

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10.

Ahmadzadeh A et. al. (2014) Genes associated with low serum high-density lipoprotein cholesterol.

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11.

Bauer RC et. al. (2015) Tribbles-1: a novel regulator of hepatic lipid metabolism in humans.

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12.

Iwamoto S et. al. (2015) The role of TRIB1 in lipid metabolism; from genetics to pathways.

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13.

Kahali B et. al. (2015) Insights from Genome-Wide Association Analyses of Nonalcoholic Fatty Liver Disease.

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14.

Stein SJ et. al. (2015) Tribbles in normal and malignant haematopoiesis.

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15.

Eyers PA et. al. (2017) Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease.

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Update: Sept. 26, 2018