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Tribbles homolog 1

The TRIB1 gene encodes a regulator of the carbohydrate metabolism with implications on lipid metabolism. Therefore in genome-wide association studies this locus is found connected with lipid disorders and coronary artery disease. The exact mechanism by which this protein exerts its effect is yet unknown.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Disturbed regulators of lipid and carbohydrate metabolism
GCKR
GPD1
MLXIPL
TRIB1

References:

1.

Wilkin F et al. (1997) Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells.

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2.

Eyers PA et al. (2017) Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease.

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3.

Stein SJ et al. (2015) Tribbles in normal and malignant haematopoiesis.

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4.

Kahali B et al. (2015) Insights from Genome-Wide Association Analyses of Nonalcoholic Fatty Liver Disease.

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5.

Iwamoto S et al. (2015) The role of TRIB1 in lipid metabolism; from genetics to pathways.

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6.

Bauer RC et al. (2015) Tribbles-1: a novel regulator of hepatic lipid metabolism in humans.

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7.

Ahmadzadeh A et al. (2014) Genes associated with low serum high-density lipoprotein cholesterol.

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8.

Bauer RC et al. (2011) Functional validation of new pathways in lipoprotein metabolism identified by human genetics.

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9.

Hegedus Z et al. (2006) Tribbles: novel regulators of cell function; evolutionary aspects.

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10.

Yoshida A et al. (2013) COP1 targets C/EBPα for degradation and induces acute myeloid leukemia via Trib1.

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11.

Satoh T et al. (2013) Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages.

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12.

Kiss-Toth E et al. (2004) Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.

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13.

Storlazzi CT et al. (2004) Identification of a commonly amplified 4.3 Mb region with overexpression of C8FW, but not MYC in MYC-containing double minutes in myeloid malignancies.

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14.

Wu M et al. (2003) SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription.

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15.

Cefalù AB et al. () Identification of a novel LMF1 nonsense mutation responsible for severe hypertriglyceridemia by targeted next-generation sequencing.

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16.

NCBI article

NCBI 10221 external link
17.

OMIM.ORG article

Omim 609461 external link
18.

Wikipedia article

Wikipedia EN (TRIB1) external link
Update: Aug. 14, 2020
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