Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The LIPG gene encodes a lipase which is involved in intravascular lipolysis. Therefore it is a probably candidate for mutation in hypertriglyceridemia.
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Clinic | Method | Massive parallel sequencing |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
Combined familial hyperlipidemia with dysfunctional VLDL metabolism
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ANGPTL8
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APOA1
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APOA4
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APOA5
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APOC3
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CETP
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GALNT2
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LCAT
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LIPC
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LIPG
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LPL
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RXRG
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USF1
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| 1. |
Cefalù AB et al. () Identification of a novel LMF1 nonsense mutation responsible for severe hypertriglyceridemia by targeted next-generation sequencing. 
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| 2. |
Jaye M et al. (1999) A novel endothelial-derived lipase that modulates HDL metabolism.
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| 3. |
Hirata K et al. (1999) Cloning of a unique lipase from endothelial cells extends the lipase gene family.
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| 4. |
Ishida T et al. (2003) Endothelial lipase is a major determinant of HDL level.
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| 5. |
Jin W et al. (2003) Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo.
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| 6. |
Yamakawa-Kobayashi K et al. (2003) Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children.
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| 7. |
Ishida T et al. (2004) Molecular cloning of nonsecreted endothelial cell-derived lipase isoforms.
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| 8. |
Ishida T et al. (2004) Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice.
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| 9. |
NCBI article NCBI 9388
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| 10. |
OMIM.ORG article Omim 603684
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| 11. |
Wikipedia article Wikipedia EN (Endothelial_lipase)
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