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SLIT-ROBO Rho GTPase-activating protein 1

The SRGAP1-gene encodes a protein that functions as a GTPase activator ind is thereby involved in signal tranduction. Mutations cause autosomal dominant non-medullary thyroid cancer 2.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Non-medullary thyroid cancer 2
SRGAP1

References:

1.

Nagase T et al. (2000) Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

external link
2.

He H et al. (2013) SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility.

external link
3.

Wong K et al. (2001) Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.

external link
4.

NCBI article

NCBI 57522 external link
5.

OMIM.ORG article

Omim 606523 external link
6.

Wikipedia article

Wikipedia EN (SRGAP1) external link
Update: Aug. 14, 2020
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