SLIT-ROBO Rho GTPase-activating protein 1
The SRGAP1-gene encodes a protein that functions as a GTPase activator ind is thereby involved in signal tranduction. Mutations cause autosomal dominant non-medullary thyroid cancer 2.
Nagase T et. al. (2000) Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.
Wong K et. al. (2001) Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.
He H et. al. (2013) SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility.
Update: Sept. 26, 2018