Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

SLIT-ROBO Rho GTPase-activating protein 1

The SRGAP1-gene encodes a protein that functions as a GTPase activator ind is thereby involved in signal tranduction. Mutations cause autosomal dominant non-medullary thyroid cancer 2.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Non-medullary thyroid cancer 2
SRGAP1

References:

1.

Nagase T et. al. (2000) Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

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2.

Wong K et. al. (2001) Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.

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3.

He H et. al. (2013) SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility.

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Update: Sept. 26, 2018