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Multiple inositol polyphosphate phosphatase 1

The MINPP1 gene encodes a inositol polyphosphate phosphatase which is likely to be involved in signal transduction. Mutations cause autosomal domimant follicular thyroid carcinoma.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Familial follicular thyroid carcinoma
MINPP1

References:

1.

Caffrey JJ et al. (1999) The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification.

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2.

Chi H et al. (1999) Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19.

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3.

Chi H et al. (2000) Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo.

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4.

Gimm O et al. (2001) Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas.

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5.

Orphanet article

Orphanet ID 484336 external link
6.

NCBI article

NCBI 9562 external link
7.

OMIM.ORG article

Omim 605391 external link
8.

Wikipedia article

Wikipedia EN (MINPP1) external link
Update: Aug. 14, 2020
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