Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Monoamine oxidase B

The MAOB-Gene encodes a mitochondrial, flavin-containing, enzyme involved in oxidative deamination of amines. An association with histamine intolerance is discussed too.

Genetests:

Clinic Method Carrier testing
Turnaround 5
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25
Specimen type genomic DNA

Related Diseases:

Histamine Intolerance
AOC1
HNMT
MAOA
MAOB

References:

1.

Chen ZY et. al. (1992) Organization of the human monoamine oxidase genes and long-range physical mapping around them.

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2.

Chen K et. al. (2004) A spontaneous point mutation produces monoamine oxidase A/B knock-out mice with greatly elevated monoamines and anxiety-like behavior.

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3.

Grimsby J et. al. (1991) Human monoamine oxidase A and B genes exhibit identical exon-intron organization.

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4.

Whibley A et. al. (2010) Deletion of MAOA and MAOB in a male patient causes severe developmental delay, intermittent hypotonia and stereotypical hand movements.

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5.

Levy ER et. al. (1989) Localization of human monoamine oxidase-A gene to Xp11.23-11.4 by in situ hybridization: implications for Norrie disease.

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6.

Kochersperger LM et. al. (1986) Assignment of genes for human monoamine oxidases A and B to the X chromosome.

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7.

Denney RM et. al. (1982) Human liver MAO-A and MAO-B separated by immunoaffinity chromatography with MAO-B-specific monoclonal antibody.

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8.

Brunner HG et al. (1993) X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism.

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9.

Lenders JW et. al. (1996) Specific genetic deficiencies of the A and B isoenzymes of monoamine oxidase are characterized by distinct neurochemical and clinical phenotypes.

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10.

Kurth JH et. al. (1993) Association of a monoamine oxidase B allele with Parkinson's disease.

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11.

Costa-Mallen P et. al. () Characterization of the in vitro transcriptional activity of polymorphic alleles of the human monoamine oxidase-B gene.

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12.

Gassó P et. al. (2008) Association of A/G polymorphism in intron 13 of the monoamine oxidase B gene with schizophrenia in a Spanish population.

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13.

Mellick GD et. al. (1999) Variations in the monoamine oxidase B (MAOB) gene are associated with Parkinson's disease.

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14.

Bach AW et. al. (1988) cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties.

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15.

Wyatt RJ et. al. (1973) Reduced monoamine oxidase activity in platelets: a possible genetic marker for vulnerability to schizophrenia.

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16.

Rice J et. al. (1984) Platelet monoamine oxidase (MAO) activity: evidence for a single major locus.

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17.

None (1983) Biochemical genetics of catecholamines in humans.

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18.

Goldin LR et. al. (1982) Segregation and linkage studies of plasma dopamine-beta-hydroxylase (DBH), erythrocyte catechol-O-methyltransferase (COMT), and platelet monoamine oxidase (MAO): possible linkage between the ABO locus and a gene controlling DBH activity.

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19.

Chen K et. al. (1993) The deduced amino acid sequences of human platelet and frontal cortex monoamine oxidase B are identical.

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20.

Fowler JS et. al. (1996) Inhibition of monoamine oxidase B in the brains of smokers.

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21.

Grimsby J et. al. (1997) Increased stress response and beta-phenylethylamine in MAOB-deficient mice.

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22.

Checkoway H et. al. (1998) A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease.

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23.

Wu RM et. al. (2001) The COMT L allele modifies the association between MAOB polymorphism and PD in Taiwanese.

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24.

Binda C et. al. (2002) Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders.

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Update: Sept. 26, 2018