Integrin alpha-9
The ITGA9 gene encodes an alpha integrin. Its function is cell adhesion. Because of its interaction with basement membranes a pathogenetic role in FSGS is discussed as well.
Genetests:
Related Diseases:
References:
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Gast C et al. (2016) Collagen (COL4A) mutations are the most frequent mutations underlying adult focal segmental glomerulosclerosis.
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Chatterjee R et al. (2013) Targeted exome sequencing integrated with clinicopathological information reveals novel and rare mutations in atypical, suspected and unknown cases of Alport syndrome or proteinuria.
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Erle DJ et al. (1991) Novel integrin alpha and beta subunit cDNAs identified in airway epithelial cells and lung leukocytes using the polymerase chain reaction.
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Palmer EL et al. (1993) Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle.
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Hibi K et al. (1994) Aberrant upregulation of a novel integrin alpha subunit gene at 3p21.3 in small cell lung cancer.
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Yamakawa K et al. (1993) Frequent homozygous deletions in lung cancer cell lines detected by a DNA marker located at 3p21.3-p22.
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Daigo Y et al. (1999) Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3.
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8. |
Staniszewska I et al. (2007) Interaction of alpha9beta1 integrin with thrombospondin-1 promotes angiogenesis.
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NCBI article
NCBI 3680
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OMIM.ORG article
Omim 603963
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11. |
Wikipedia article
Wikipedia EN (Integrin_alpha_9)
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Update: Aug. 14, 2020