Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Integrin alpha-9

The ITGA9 gene encodes an alpha integrin. Its function is cell adhesion. Because of its interaction with basement membranes a pathogenetic role in FSGS is discussed as well.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Focal, segmental glomerulosclerosis (FSGS)
ALG13
ARHGAP24
CLU
Hereditary FSGS type 1
ACTN4
Hereditary FSGS type 2
TRPC6
Hereditary FSGS type 3
CD2AP
Hereditary FSGS type 4
APOL1
Hereditary FSGS type 5
INF2
Hereditary FSGS type 6
MYO1E
Hereditary FSGS type 7
PAX2
ITGA9
LAMA5
NXF5

References:

1.

Gast C et al. (2016) Collagen (COL4A) mutations are the most frequent mutations underlying adult focal segmental glomerulosclerosis.

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2.

Chatterjee R et al. (2013) Targeted exome sequencing integrated with clinicopathological information reveals novel and rare mutations in atypical, suspected and unknown cases of Alport syndrome or proteinuria.

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3.

Erle DJ et al. (1991) Novel integrin alpha and beta subunit cDNAs identified in airway epithelial cells and lung leukocytes using the polymerase chain reaction.

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4.

Palmer EL et al. (1993) Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle.

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5.

Hibi K et al. (1994) Aberrant upregulation of a novel integrin alpha subunit gene at 3p21.3 in small cell lung cancer.

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6.

Yamakawa K et al. (1993) Frequent homozygous deletions in lung cancer cell lines detected by a DNA marker located at 3p21.3-p22.

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7.

Daigo Y et al. (1999) Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3.

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8.

Staniszewska I et al. (2007) Interaction of alpha9beta1 integrin with thrombospondin-1 promotes angiogenesis.

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9.

NCBI article

NCBI 3680 external link
10.

OMIM.ORG article

Omim 603963 external link
11.

Wikipedia article

Wikipedia EN (Integrin_alpha_9) external link
Update: Aug. 14, 2020
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