Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Fibroblast growth factor 10

The FGF10 gene encodes a fibroblast growth factor which is involved in development of brain, lung and limbs ans also wound healing. Mutations cause autosomal dominant disorders Aplasia of lacrimal and salivary glands and Lacrimoauriculodentodigital syndrome.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Research Method Multiplex Ligation-Dependent Probe Amplification
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Aplasia of lacrimal and salivary glands
FGF10
Lacrimoauriculodentodigital syndrome
FGF10

References:

1.

Rohmann E et al. (2006) Mutations in different components of FGF signaling in LADD syndrome.

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2.

Rice R et al. (2004) Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate.

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3.

Watanabe Y et al. (2010) Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries.

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4.

Entesarian M et al. (2005) Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands.

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5.

Milunsky JM et al. (2006) LADD syndrome is caused by FGF10 mutations.

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6.

Entesarian M et al. (2007) FGF10 missense mutations in aplasia of lacrimal and salivary glands (ALSG).

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7.

Klar J et al. (2011) Fibroblast growth factor 10 haploinsufficiency causes chronic obstructive pulmonary disease.

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8.

Emoto H et al. (1997) Structure and expression of human fibroblast growth factor-10.

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9.

Min H et al. (1998) Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless.

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10.

Sekine K et al. (1999) Fgf10 is essential for limb and lung formation.

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11.

None (1999) Morphogenesis.

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12.

Suzuki K et al. (2000) Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf10 gene.

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13.

Kelly RG et al. (2001) The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm.

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14.

Bagai S et al. (2002) Fibroblast growth factor-10 is a mitogen for urothelial cells.

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15.

Sakaue H et al. (2002) Requirement of fibroblast growth factor 10 in development of white adipose tissue.

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16.

Umemori H et al. (2004) FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain.

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17.

Nechiporuk A et al. (2008) FGF-dependent mechanosensory organ patterning in zebrafish.

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18.

Frenz DA et al. (2010) Retinoid signaling in inner ear development: A "Goldilocks" phenomenon.

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19.

Gros J et al. (2014) Vertebrate limb bud formation is initiated by localized epithelial-to-mesenchymal transition.

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20.

Orphanet article

Orphanet ID 121794 [^]
21.

NCBI article

NCBI 2255 [^]
22.

OMIM.ORG article

Omim 602115 [^]
23.

Wikipedia article

Wikipedia EN (FGF10) [^]
Update: April 29, 2019