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Fibroblast growth factor 10

The FGF10 gene encodes a fibroblast growth factor which is involved in development of brain, lung and limbs ans also wound healing. Mutations cause autosomal dominant disorders Aplasia of lacrimal and salivary glands and Lacrimoauriculodentodigital syndrome.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Research Method Multiplex Ligation-Dependent Probe Amplification
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Aplasia of lacrimal and salivary glands
FGF10
Lacrimoauriculodentodigital syndrome
FGF10

References:

1.

Rice R et al. (2004) Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate.

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2.

Gros J et al. (2014) Vertebrate limb bud formation is initiated by localized epithelial-to-mesenchymal transition.

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3.

Frenz DA et al. (2010) Retinoid signaling in inner ear development: A "Goldilocks" phenomenon.

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4.

Nechiporuk A et al. (2008) FGF-dependent mechanosensory organ patterning in zebrafish.

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5.

Umemori H et al. (2004) FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain.

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6.

Sakaue H et al. (2002) Requirement of fibroblast growth factor 10 in development of white adipose tissue.

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7.

Bagai S et al. (2002) Fibroblast growth factor-10 is a mitogen for urothelial cells.

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8.

Kelly RG et al. (2001) The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm.

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9.

Suzuki K et al. (2000) Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf10 gene.

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10.

None (1999) Morphogenesis.

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11.

Sekine K et al. (1999) Fgf10 is essential for limb and lung formation.

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12.

Min H et al. (1998) Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless.

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13.

Emoto H et al. (1997) Structure and expression of human fibroblast growth factor-10.

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14.

Klar J et al. (2011) Fibroblast growth factor 10 haploinsufficiency causes chronic obstructive pulmonary disease.

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15.

Entesarian M et al. (2007) FGF10 missense mutations in aplasia of lacrimal and salivary glands (ALSG).

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16.

Milunsky JM et al. (2006) LADD syndrome is caused by FGF10 mutations.

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17.

Entesarian M et al. (2005) Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands.

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18.

Watanabe Y et al. (2010) Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries.

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19.

Rohmann E et al. (2006) Mutations in different components of FGF signaling in LADD syndrome.

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20.

Orphanet article

Orphanet ID 121794 external link
21.

NCBI article

NCBI 2255 external link
22.

OMIM.ORG article

Omim 602115 external link
23.

Wikipedia article

Wikipedia EN (FGF10) external link
Update: Aug. 14, 2020
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