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Plasminogen

The PLG gene encodes plasminogen which is a zymogen which when activated digests fibin thrombi. Mutations cause autosomal recessive plasminogen deficiency and conjunctivitis lignosa. The cleaved off peptice has angiostatic activity. No disorder is yet known that is caused by dysfunction of that peptide.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Dysplasminogenemia
PLG
Hypoplasminogenemia
PLG
Hemolytic-Uremic Syndrome
ADAMTS13
C3
C4BPA
C4BPB
CD46
CFB
CFH
CFHR1
CFHR2
CFHR3
CFHR4
CFHR5
CFI
CLU
DGKE
Methylmalonic aciduria
Methylmalonic aciduria and homocystinuria cblC
MMACHC
Methylmalonic aciduria and homocystinuria cblD
MMADHC
Methylmalonic aciduria type mut
MUT
PIGA
PLG
THBD

References:

1.

Gately S et al. (1996) Human prostate carcinoma cells express enzymatic activity that converts human plasminogen to the angiogenesis inhibitor, angiostatin.

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2.

Miyata T et al. (1984) Plasminogens Tochigi II and Nagoya: two additional molecular defects with Ala-600----Thr replacement found in plasmin light chain variants.

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3.

Sakata Y et al. (1980) Molecular abnormality of plasminogen.

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4.

Eiberg H et al. (1984) Linkage of plasma alpha-L-fucosidase (FUCA2) and the plasminogen (PLG) system.

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5.

Bissbort S et al. (1983) Genetic linkage relations of the human plasminogen gene.

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6.

Nakamura S et al. (1982) Genetic polymorphism of human plasminogen in the Japanese population: new plasminogen variants and relationship between plasminogen phenotypes and their biological activities.

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7.

Ikemoto S et al. (1982) Genetic polymorphism of human plasminogen in a Japanese population.

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8.

Kazama M et al. () Abnormal plasminogen, a case of recurrent thrombosis.

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9.

Raum D et al. (1980) Genetic polymorphism of human plasminogen.

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10.

Magnaghi P et al. (1995) A recombination event in the closely linked plasminogen and apolipoprotein(a) gene loci.

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11.

Ploplis VA et al. (1995) Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice.

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12.

Bugge TH et al. (1995) Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.

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13.

Rao PH et al. (1994) Subregional mapping of 8 single copy loci to chromosome 6 by fluorescence in situ hybridization.

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14.

Patrassi GM et al. (1993) Unusual thrombotic-like retinopathy (Coats' disease) associated with congenital plasminogen deficiency type I.

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15.

Azuma H et al. (1993) Congenital plasminogen deficiency caused by a Ser572 to Pro mutation.

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16.

Romer J et al. (1996) Impaired wound healing in mice with a disrupted plasminogen gene.

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17.

Kunert A et al. (2007) Immune evasion of the human pathogen Pseudomonas aeruginosa: elongation factor Tuf is a factor H and plasminogen binding protein.

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18.

Cao Y et al. (1996) Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells.

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19.

Boyle MD et al. (1997) Plasminogen activation by invasive human pathogens.

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20.

Kida M et al. (1997) Characterization of the 5'-flanking regions of plasminogen-related genes A and B.

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21.

Murata M et al. (1997) Ala601-Thr type dysplasminogenaemia genetically diagnosed in patients with retinochoroidal vascular disorders.

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22.

Cao Y et al. (1998) Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases.

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23.

Iijima H et al. (1998) Familial dysplasminogenemia with central retinal vein and cilioretinal artery occlusion.

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24.

Higuchi Y et al. (1998) Plasminogen Kanagawa-I, a novel missense mutation, is caused by the amino acid substitution G732R.

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25.

Gebbia JA et al. (1999) The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis.

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26.

Fischer MB et al. (2000) Binding of disease-associated prion protein to plasminogen.

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27.

Drixler TA et al. (2001) Angiostatin inhibits pathological but not physiological retinal angiogenesis.

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28.

Swaisgood CM et al. (2002) In vivo regulation of plasminogen function by plasma carboxypeptidase B.

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29.

Lund LR et al. (2006) Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.

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30.

Nguyen TM et al. (2007) Kringle 5 of human plasminogen, an angiogenesis inhibitor, induces both autophagy and apoptotic death in endothelial cells.

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31.

Gong Y et al. (2008) Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice.

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32.

Miyata T et al. (1982) Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site.

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33.

O'Reilly MS et al. (1994) Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.

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34.

Soria J et al. (1983) Plasminogen Paris I: congenital abnormal plasminogen and its incidence in thrombosis.

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35.

McLean JW et al. () cDNA sequence of human apolipoprotein(a) is homologous to plasminogen.

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36.

Aoki N et al. (1978) Abnormal plasminogen. A hereditary molecular abnormality found in a patient with recurrent thrombosis.

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37.

Shigekiyo T et al. (1992) Type I congenital plasminogen deficiency is not a risk factor for thrombosis.

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38.

None (1990) Ligneous conjunctivitis: an ophthalmic disease with potentially fatal tracheobronchial obstruction. Laryngeal and tracheobronchial features.

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39.

Dolan G et al. (1988) Thrombovascular disease and familial plasminogen deficiency: a report of three kindreds.

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40.

Bateman JB et al. () Ligneous conjunctivitis: an autosomal recessive disorder.

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41.

Tait RC et al. (1996) Isolated familial plasminogen deficiency may not be a risk factor for thrombosis.

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42.

Schuster V et al. (1997) Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis.

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43.

Drew AF et al. (1998) Ligneous conjunctivitis in plasminogen-deficient mice.

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44.

Kao WW et al. (1998) Healing of corneal epithelial defects in plasminogen- and fibrinogen-deficient mice.

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45.

Schott D et al. (1998) Therapy with a purified plasminogen concentrate in an infant with ligneous conjunctivitis and homozygous plasminogen deficiency.

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46.

Schuster V et al. (1999) Compound-heterozygous mutations in the plasminogen gene predispose to the development of ligneous conjunctivitis.

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47.

Tefs K et al. (2006) Molecular and clinical spectrum of type I plasminogen deficiency: A series of 50 patients.

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48.

Wohl RC et al. (1982) Human plasminogen variant Chicago III.

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49.

Mannucci PM et al. (1986) Congenital plasminogen deficiency associated with venous thromboembolism: therapeutic trial with stanozolol.

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50.

Hach-Wunderle V et al. (1988) Congenital deficiency of plasminogen and its relationship to venous thrombosis.

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51.

Forsgren M et al. (1987) Molecular cloning and characterization of a full-length cDNA clone for human plasminogen.

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52.

Wu HL et al. (1987) Structure and formation of microplasmin.

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53.

Wu HL et al. (1987) Preparation and purification of microplasmin.

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54.

Scharrer IM et al. (1986) Investigation of a congenital abnormal plasminogen, Frankfurt I, and its relationship to thrombosis.

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55.

Murray JC et al. (1987) Linkage disequilibrium of plasminogen polymorphisms and assignment of the gene to human chromosome 6q26-6q27.

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56.

Petersen TE et al. (1990) Characterization of the gene for human plasminogen, a key proenzyme in the fibrinolytic system.

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57.

Degen SJ et al. (1990) Characterization of the cDNA coding for mouse plasminogen and localization of the gene to mouse chromosome 17.

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58.

Ichinose A et al. (1991) Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis.

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59.

Kikuchi S et al. () Plasminogen with type-I mutation is polymorphic in the Japanese population.

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60.

None (1979) Genetic polymorphism of human plasminogen.

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61.

Schuster V et al. () Ligneous conjunctivitis.

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62.

NCBI article

NCBI 5340 external link
63.

OMIM.ORG article

Omim 173350 external link
64.

Orphanet article

Orphanet ID 117886 external link
65.

Wikipedia article

Wikipedia EN (Plasmin) external link
Update: Aug. 14, 2020
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