Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Proline-rich protein PRCC

The PRCC gene encodes a protein that is involved in mRNA splicing. Translocations that involve this gene causse renal papillary carcinoma.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Hereditary papillary renal cell carcinoma
Hereditary papillary renal cell carcinoma 1
MET
PRCC

References:

1.

de Jong B et al. (1986) Cytogenetics of a renal adenocarcinoma in a 2-year-old child.

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2.

Meloni AM et al. (1993) Translocation (X;1) in papillary renal cell carcinoma. A new cytogenetic subtype.

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3.

Sidhar SK et al. (1996) The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene.

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4.

Weterman MA et al. (1996) Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas.

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5.

Weterman MA et al. (2001) Genomic structure, chromosomal localization, and embryonic expression of the mouse homolog of PRCC, a gene associated with papillary renal cell carcinoma.

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6.

Orphanet article

Orphanet ID 117989 [^]
7.

NCBI article

NCBI 5546 [^]
8.

OMIM.ORG article

Omim 179755 [^]
9.

Wikipedia article

Wikipedia EN (PRCC_(gene)) [^]
Update: April 29, 2019