Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Insulin-like growth factor-binding protein 3

The IGFBP3 gene encodes a protein that interacts with IGF and prolonges its half-life. Therefore a posible role in growth regulations is hypothized.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Multiplex Ligation-Dependent Probe Amplification
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Growth hormone insensitivity
Growth hormone insensitivity with immunodeficiency
STAT5B
IGFBP3
Insulin-like growth factor 1 deficiency
IGF1
Insulin-like growth factor 1 resistance
IGF1R
Insulin-like growth factor 1 transport protein deficiency
IGFALS
Laron syndrome
GHR
SH2B1

References:

1.

Ehrenborg E et. al. (1992) Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7.

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2.

Wood WI et. al. (1988) Cloning and expression of the growth hormone-dependent insulin-like growth factor-binding protein.

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3.

Ballard J et. al. (1989) On the nomenclature of the IGF binding proteins.

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4.

Ferry RJ et. al. (1999) Insulin-like growth factor binding proteins: new proteins, new functions.

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5.

Fraser HM et. al. (2000) Changes in insulin-like growth factor-binding protein-3 messenger ribonucleic acid in endothelial cells of the human corpus luteum: a possible role in luteal development and rescue.

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6.

Deal C et. al. (2001) Novel promoter polymorphism in insulin-like growth factor-binding protein-3: correlation with serum levels and interaction with known regulators.

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7.

Weinzimer SA et. al. (2001) Transferrin is an insulin-like growth factor-binding protein-3 binding protein.

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8.

Popovici RM et. al. (2001) Hypoxia regulates insulin-like growth factor-binding protein 1 in human fetal hepatocytes in primary culture: suggestive molecular mechanisms for in utero fetal growth restriction caused by uteroplacental insufficiency.

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9.

Buckway CK et. al. (2001) Mutation of three critical amino acids of the N-terminal domain of IGF-binding protein-3 essential for high affinity IGF binding.

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10.

Spagnoli A et. al. (2002) Identification of STAT-1 as a molecular target of IGFBP-3 in the process of chondrogenesis.

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11.

Spoerri PE et. al. (2003) Expression of IGFBP-3 by human retinal endothelial cell cultures: IGFBP-3 involvement in growth inhibition and apoptosis.

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12.

Geary MP et al. (2003) Sexual dimorphism in the growth hormone and insulin-like growth factor axis at birth.

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13.

Cheng I et. al. (2007) Genetic determinants of circulating insulin-like growth factor (IGF)-I, IGF binding protein (BP)-1, and IGFBP-3 levels in a multiethnic population.

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14.

Chang KH et. al. (2007) IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development.

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15.

Lofqvist C et. al. (2007) IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth.

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Update: Sept. 26, 2018