Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Natriuretic peptide type C

The NPPC gene encodes a peptide hormone involved in water and sodium balance.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

References:

1.

Yasoda A et al. (2004) Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway.

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2.

Sudoh T et al. (1990) C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain.

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3.

Minamino N et al. (1990) N-terminally extended form of C-type natriuretic peptide (CNP-53) identified in porcine brain.

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4.

Ogawa Y et al. (1994) Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC).

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5.

Suda M et al. (1998) Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide.

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6.

Yasoda A et al. (1998) Natriuretic peptide regulation of endochondral ossification. Evidence for possible roles of the C-type natriuretic peptide/guanylyl cyclase-B pathway.

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7.

Chusho H et al. (2001) Dwarfism and early death in mice lacking C-type natriuretic peptide.

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8.

Zhang M et al. (2010) Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes.

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9.

NCBI article

NCBI 4880 [^]
10.

OMIM.ORG article

Omim 600296 [^]
11.

Wikipedia article

Wikipedia EN (Natriuretic_peptide_precursor_C) [^]
Update: April 29, 2019