Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Cytoplasmic isocitrate dehydrogenase [NADP]

The IDH1 gene encodes a zytoplastmatic enzyme of the citrate metabolism. Genetic variants in that gene seem to be associated with glioma.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Multiplex Ligation-Dependent Probe Amplification
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Susceptibility to glioma
IDH1

References:

1.

Weil D et. al. (1977) [Regional localization of the genes for human IDHs, MDHs PGK, alphaGAL, G6PD by interspecific hybridization (author's transl)].

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2.

Narahara K et. al. (1985) Probable assignment of soluble isocitrate dehydrogenase (IDH1) to 2q33.3.

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3.

Boone C et. al. (1972) Assignment of three human genes to chromosomes (LDH-A to 11, TK to 17, and IDH to 20) and evidence for translocation between human and mouse chromosomes in somatic cell hybrids (thymidine kinase-lactate dehydrogenase A-isocitrate dehydrogenase-C-11, E-17, and F-20 chromosomes).

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4.

Chen SH et. al. (1972) Genetic variation of the soluble form of NADP-dependent isocitric dehydrogenase in man.

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5.

None (1972) Genetics of human-mouse somatic cell hybrids: linkage of human genes for isocitrate dehydrogenase and malate dehydrogenase.

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6.

None (1968) Intracellular location and genetic control of isozymes of NADP-dependent isocitrate dehydrogenase and malate dehydrogenase.

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7.

Turner BM et. al. (1974) An account of two new ICD-S variants not detectable in red blood cells.

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8.

Creagan RP et. al. (1974) Chromosome assignments of genes in man using mouse-human somatic cell hybrids: Cytoplasmic isocitrate dehydrogenase (IDH 1) and malate dehydrogenase (MDH 1) to chromosomes 2.

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9.

None (1973) Linkage analysis in man by somatic cell genetics.

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10.

Nekrutenko A et. al. (1998) Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family.

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11.

Geisbrecht BV et. al. (1999) The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase.

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12.

Shechter I et. al. (2003) IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: evidence that IDH1 may regulate lipogenesis in hepatic cells.

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13.

None (1965) ISOZYMES OF ISOCITRATE DEHYDROGENASE: SUBUNIT STRUCTURE AND INTRACELLULAR LOCATION.

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14.

Xu X et. al. (2004) Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity.

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15.

Memon AA et. al. (2005) Identification of differentially expressed proteins during human urinary bladder cancer progression.

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16.

Ronnebaum SM et. al. (2006) A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion.

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17.

Parsons DW et. al. (2008) An integrated genomic analysis of human glioblastoma multiforme.

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18.

Aghili M et. al. (2009) Hydroxyglutaric aciduria and malignant brain tumor: a case report and literature review.

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19.

Yan H et. al. (2009) IDH1 and IDH2 mutations in gliomas.

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20.

Zhao S et. al. (2009) Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.

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21.

Mardis ER et. al. (2009) Recurring mutations found by sequencing an acute myeloid leukemia genome.

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22.

Dubbink HJ et. al. (2009) IDH1 mutations in low-grade astrocytomas predict survival but not response to temozolomide.

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23.

Dang L et. al. (2009) Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.

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24.

Schnittger S et. al. (2010) IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status.

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25.

Bralten LB et. al. (2011) IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo.

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26.

Turcan S et. al. (2012) IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.

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27.

Koivunen P et. al. (2012) Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

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28.

Lu C et. al. (2012) IDH mutation impairs histone demethylation and results in a block to cell differentiation.

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29.

Sasaki M et. al. (2012) IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics.

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30.

Losman JA et. al. (2013) (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible.

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31.

Rohle D et. al. (2013) An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

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32.

et. al. (2013) Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.

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33.

Miller CA et. al. (2013) Genomic landscapes and clonality of de novo AML.

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34.

Brewin J et. al. (2013) Genomic landscapes and clonality of de novo AML.

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35.

Saha SK et. al. (2014) Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.

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36.

Schumacher T et. al. (2014) A vaccine targeting mutant IDH1 induces antitumour immunity.

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37.

Flavahan WA et. al. (2016) Insulator dysfunction and oncogene activation in IDH mutant gliomas.

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Update: Sept. 26, 2018