Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Interleukin-13

The IL13 gene encodes interleukin-13, an impotant cytokine secreted by T-helper-lymphocytes 2. It plays an important role in regulation of immune processes such as susceptibility to asthma and allergic rhinitis.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Susceptibility to allergic rhinitis
IL13
Susceptibility to asthma
IL13

References:

1.

Morgan JG et. al. (1992) The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes.

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2.

Smirnov DV et. al. (1995) Tandem arrangement of human genes for interleukin-4 and interleukin-13: resemblance in their organization.

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3.

Zurawski G et. al. (1994) Interleukin 13 elicits a subset of the activities of its close relative interleukin 4.

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4.

Minty A et. al. (1993) Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses.

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5.

Punnonen J et. al. (1993) Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.

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6.

McKenzie AN et. al. (1993) Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function.

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7.

Wills-Karp M et. al. (1998) Interleukin-13: central mediator of allergic asthma.

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8.

Grünig G et. al. (1998) Requirement for IL-13 independently of IL-4 in experimental asthma.

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9.

Zhu Z et. al. (1999) Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.

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10.

Heinzmann A et. al. (2000) Genetic variants of IL-13 signalling and human asthma and atopy.

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11.

Loots GG et. al. (2000) Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons.

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12.

Lacy DA et. al. (2000) Faithful expression of the human 5q31 cytokine cluster in transgenic mice.

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13.

Zheng T et. al. (2000) Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema.

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14.

Howard TD et. al. (2001) Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population.

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15.

Howard TD et. al. (2002) Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma.

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16.

Kuperman DA et. al. (2002) Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma.

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17.

Lanone S et. al. (2002) Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling.

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18.

Kelly-Welch AE et. al. (2003) Interleukin-4 and interleukin-13 signaling connections maps.

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19.

He JQ et. al. (2003) Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children.

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20.

Blackburn MR et. al. (2003) Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway.

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21.

Wang M et. al. (2003) A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis.

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22.

Zhu Z et. al. (2004) Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation.

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23.

Chen W et. al. (2004) Functional effect of the R110Q IL13 genetic variant alone and in combination with IL4RA genetic variants.

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24.

Hiromatsu Y et. al. (2005) Interleukin-13 gene polymorphisms confer the susceptibility of Japanese populations to Graves' disease.

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25.

Chen Q et. al. (2005) IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling.

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26.

Vladich FD et. al. (2005) IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation.

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27.

Kouriba B et. al. (2005) Analysis of the 5q31-q33 locus shows an association between IL13-1055C/T IL-13-591A/G polymorphisms and Schistosoma haematobium infections.

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28.

Fichtner-Feigl S et. al. (2006) IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis.

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29.

LaPorte SL et. al. (2008) Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.

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30.

Neill DR et. al. (2010) Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity.

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31.

Wu D et. al. (2011) Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.

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32.

Nussbaum JC et. al. (2013) Type 2 innate lymphoid cells control eosinophil homeostasis.

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33.

Bosurgi L et. al. (2017) Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.

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Update: Sept. 26, 2018