Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Interleukin-4

The IL4 gene encodes interleukin-4, a cytokine secreted by activated T lymphocytes. It plays an important role in regulation of immune processes.

Genetests:

Clinic Method Carrier testing
Turnaround 5
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25
Specimen type genomic DNA

Related Diseases:

References:

1.

Fields PE et al. (2002) Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation.

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2.

Smirnov DV et. al. (1995) Tandem arrangement of human genes for interleukin-4 and interleukin-13: resemblance in their organization.

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3.

Loots GG et. al. (2000) Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons.

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4.

Lacy DA et. al. (2000) Faithful expression of the human 5q31 cytokine cluster in transgenic mice.

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5.

Kelly-Welch AE et. al. (2003) Interleukin-4 and interleukin-13 signaling connections maps.

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6.

LaPorte SL et. al. (2008) Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.

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7.

Wu D et. al. (2011) Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.

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8.

Bosurgi L et. al. (2017) Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.

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9.

Arai N et. al. (1989) Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression.

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10.

Takahashi M et. al. (1989) Chromosomal mapping of the mouse IL-4 and human IL-5 genes.

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11.

Le Beau MM et. al. (1989) Interleukin-4 and interleukin-5 map to human chromosome 5 in a region encoding growth factors and receptors and are deleted in myeloid leukemias with a del(5q).

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12.

Yokota T et. al. (1986) Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.

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13.

Eder A et. al. (1988) The 5' region of the human interleukin 4 gene: structure and potential regulatory elements.

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14.

Sutherland GR et. al. (1988) Interleukin 4 is at 5q31 and interleukin 6 is at 7p15.

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15.

Leung DY et. al. (1988) Clinical and immunologic aspects of the hyperimmunoglobulin E syndrome.

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16.

Lewis DB et. al. (1993) Osteoporosis induced in mice by overproduction of interleukin 4.

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17.

Saltman DL et. al. (1993) A physical map of 15 loci on human chromosome 5q23-q33 by two-color fluorescence in situ hybridization.

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18.

Le Beau MM et. al. (1993) Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases.

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19.

Kotanides H et. al. (1996) Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene.

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20.

Kawashima T et. al. (1998) Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families.

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21.

Dickensheets HL et. al. (1999) Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression.

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22.

Hunt PJ et. al. (2000) Cytokine gene polymorphisms in autoimmune thyroid disease.

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23.

Carvalho LH et. al. (2002) IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages.

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24.

Inoue T et. al. (2002) Contribution of the interleukin 4 gene to susceptibility to subacute sclerosing panencephalitis.

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25.

Ozaki K et. al. (2002) A critical role for IL-21 in regulating immunoglobulin production.

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26.

Messi M et al. (2003) Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes.

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27.

Ghoreschi K et. al. (2003) Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease.

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28.

Horsley V et. al. (2003) IL-4 acts as a myoblast recruitment factor during mammalian muscle growth.

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29.

Zavros Y et. al. (2003) Treatment of Helicobacter gastritis with IL-4 requires somatostatin.

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30.

Zee RY et. al. (2004) Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis.

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31.

Spilianakis CG et al. (2005) Interchromosomal associations between alternatively expressed loci.

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32.

Nguyen KD et. al. (2011) Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis.

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33.

Vijayanand P et. al. (2012) Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V.

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34.

Harada Y et. al. (2012) The 3' enhancer CNS2 is a critical regulator of interleukin-4-mediated humoral immunity in follicular helper T cells.

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35.

Reese TA et. al. (2014) Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter.

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36.

Osborne LC et. al. (2014) Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation.

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37.

Minutti CM et. al. (2017) Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver.

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Update: Sept. 26, 2018