Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

High affinity immunoglobulin epsilon receptor subunit beta

The MS4A2 gene encodes a receptor for immunoglobulin E and is therefore involved in the regulation of autoimmune reactions. Mutations cause autosomal dominant susceptibility to atopy.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Atopy
MS4A2

References:

1.

Küster H et. al. (1992) The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor.

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2.

Hupp K et. al. (1989) Gene mapping of the three subunits of the high affinity FcR for IgE to mouse chromosomes 1 and 19.

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3.

Hizawa N et. al. (1995) Association between high serum total IgE levels and D11S97 on chromosome 11q13 in Japanese subjects.

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4.

Shirakawa T et. al. (1994) Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor.

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5.

Sandford AJ et. al. (1993) Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q.

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6.

Szepetowski P et. al. (1994) FCER1B, a candidate gene for atopy, is located in 11q13 between CD20 and TCN1.

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7.

Hill MR et. al. (1996) A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness.

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8.

Shirakawa T et. al. (1996) Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population.

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9.

Fölster-Holst R et. al. (1998) Linkage between atopy and the IgE high-affinity receptor gene at 11q13 in atopic dermatitis families.

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10.

Nagata H et. al. (2001) Association between nasal allergy and a coding variant of the Fc epsilon RI beta gene Glu237Gly in a Japanese population.

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11.

Donnadieu E et. al. (2003) Competing functions encoded in the allergy-associated F(c)epsilonRIbeta gene.

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12.

Traherne JA et. al. (2003) LD mapping of maternally and non-maternally derived alleles and atopy in FcepsilonRI-beta.

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13.

Cruse G et. al. (2010) A novel FcεRIβ-chain truncation regulates human mast cell proliferation and survival.

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14.

Cruse G et. al. (2013) A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells.

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Update: Sept. 26, 2018