Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

High affinity immunoglobulin epsilon receptor subunit beta

The MS4A2 gene encodes a receptor for immunoglobulin E and is therefore involved in the regulation of autoimmune reactions. Mutations cause autosomal dominant susceptibility to atopy.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Atopy
MS4A2

References:

1.

Sandford AJ et al. (1993) Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q.

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2.

Cruse G et al. (2013) A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells.

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3.

Cruse G et al. (2010) A novel FcεRIβ-chain truncation regulates human mast cell proliferation and survival.

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4.

Traherne JA et al. (2003) LD mapping of maternally and non-maternally derived alleles and atopy in FcepsilonRI-beta.

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5.

Donnadieu E et al. (2003) Competing functions encoded in the allergy-associated F(c)epsilonRIbeta gene.

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6.

Nagata H et al. (2001) Association between nasal allergy and a coding variant of the Fc epsilon RI beta gene Glu237Gly in a Japanese population.

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7.

Fölster-Holst R et al. (1998) Linkage between atopy and the IgE high-affinity receptor gene at 11q13 in atopic dermatitis families.

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8.

Shirakawa T et al. (1996) Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population.

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9.

Hill MR et al. (1996) A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness.

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10.

Szepetowski P et al. (1994) FCER1B, a candidate gene for atopy, is located in 11q13 between CD20 and TCN1.

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11.

Shirakawa T et al. (1994) Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor.

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12.

Hupp K et al. (1989) Gene mapping of the three subunits of the high affinity FcR for IgE to mouse chromosomes 1 and 19.

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13.

Küster H et al. (1992) The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor.

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14.

Hizawa N et al. (1995) Association between high serum total IgE levels and D11S97 on chromosome 11q13 in Japanese subjects.

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15.

NCBI article

NCBI 2206 external link
16.

OMIM.ORG article

Omim 147138 external link
17.

Wikipedia article

Wikipedia EN (MS4A2) external link
Update: Aug. 14, 2020
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