Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Atrial natriuretic peptide-converting enzyme

The CORIN gene encodes a serine protease that activates atrial natriuretic peptide in cardiac myocytes. Some mutations have been associated with preeclampsia 5.

Genetests:

Clinic Method Carrier testing
Turnaround 5
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25
Specimen type genomic DNA

Related Diseases:

Susceptibility to glioma
IDH1

References:

1.

Yan W et. al. (1999) Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart.

[^]
2.

Yan W et. al. (2000) Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme.

[^]
3.

Pan J et. al. (2002) Genomic structures of the human and murine corin genes and functional GATA elements in their promoters.

[^]
4.

Knappe S et. al. (2003) Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin.

[^]
5.

Dries DL et. al. (2005) Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension.

[^]
6.

Guipponi M et. al. (2008) An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss.

[^]
7.

Wang W et. al. (2008) Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity.

[^]
8.

Cui Y et. al. (2012) Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy.

[^]
9.

Dong N et. al. (2013) Corin mutation R539C from hypertensive patients impairs zymogen activation and generates an inactive alternative ectodomain fragment.

[^]
10.

Dong N et. al. (2014) Corin mutations K317E and S472G from preeclamptic patients alter zymogen activation and cell surface targeting. [Corrected].

[^]
Update: Sept. 26, 2018