Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Storkhead-box protein 1

The STOX1 gene encodes a DNA-binding protein. Mutations are made responsible for preeclampsia 4.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Noonan syndrome-like disorder and juvenile myelomonocytic leukemia
CBL

References:

1.

van Dijk M et. al. (2005) Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family.

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2.

Oudejans CB et. al. (2007) Genetics of preeclampsia: paradigm shifts.

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3.

Kivinen K et. al. (2007) Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample.

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4.

Iglesias-Platas I et. al. (2007) STOX1 is not imprinted and is not likely to be involved in preeclampsia.

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5.

van Dijk M et. al. (2010) The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation.

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Update: Sept. 26, 2018