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Prokineticin-2

The PROK2 gene encodes a neuropeptide which is predominantly expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. Mutations autosomal dominant Kallmann syndrome 4.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

References:

1.

Hanchate NK et al. (2012) SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome.

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2.

Dodé C et al. (2006) Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2.

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3.

Pitteloud N et al. (2007) Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism.

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4.

Leroy C et al. (2008) Biallelic mutations in the prokineticin-2 gene in two sporadic cases of Kallmann syndrome.

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5.

Cole LW et al. (2008) Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum.

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6.

Jilek A et al. (2000) Murine Bv8 gene maps near a synteny breakpoint of mouse chromosome 6 and human 3p21.

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7.

Li M et al. (2001) Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle.

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8.

Cheng MY et al. (2002) Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus.

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9.

Ng KL et al. (2005) Dependence of olfactory bulb neurogenesis on prokineticin 2 signaling.

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10.

Shojaei F et al. (2007) Bv8 regulates myeloid-cell-dependent tumour angiogenesis.

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11.

Giannini E et al. (2009) The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain.

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Update: Aug. 14, 2020
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