Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
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Interleukin-10 receptor subunit beta

The IL10RB gene encodes a component of the interleukin 10 receptor which is involved in IL10 signal transduction. Mutations cause autosomal recessive IL10R-Deficiency wich presents as inflammatory bowel disease 25. Also, a genetic variant predisposes to heptitis B virus persistence.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Inflammatory bowel disease 25
IL10RB
Hepatitis B susceptibility
IL10RB
Interleukin 10 receptor deficiency
IL10RA
IL10RB
Inflammatory bowel disease 25
IL10RB
Inflammatory bowel disease 28
IL10RA

References:

1.

Lutfalla G et. al. (1993) A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR.

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2.

Cheng S et. al. (1993) GART, SON, IFNAR, and CRF2-4 genes cluster on human chromosome 21 and mouse chromosome 16.

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3.

Gibbs VC et. al. (1997) CRF2-4: isolation of cDNA clones encoding the human and mouse proteins.

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4.

Kotenko SV et. al. (1997) Identification and functional characterization of a second chain of the interleukin-10 receptor complex.

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5.

Spencer SD et. al. (1998) The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor.

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6.

Sheppard P et. al. (2003) IL-28, IL-29 and their class II cytokine receptor IL-28R.

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7.

Sheikh F et. al. (2004) Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2.

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8.

Frodsham AJ et. al. (2006) Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.

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9.

Glocker EO et. al. (2009) Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.

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10.

Begue B et. al. (2011) Defective IL10 signaling defining a subgroup of patients with inflammatory bowel disease.

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11.
Update: Aug. 14, 2020
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