Stimulator of interferon genes protein

Sun L et al. (2013) Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.

Haag SM et al. (2018) Targeting STING with covalent small-molecule inhibitors.

Dou Z et al. (2017) Cytoplasmic chromatin triggers inflammation in senescence and cancer.

Harding SM et al. (2017) Mitotic progression following DNA damage enables pattern recognition within micronuclei.

Lau L et al. (2015) DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway.

Bridgeman A et al. (2015) Viruses transfer the antiviral second messenger cGAMP between cells.

Gentili M et al. (2015) Transmission of innate immune signaling by packaging of cGAMP in viral particles.

West AP et al. (2015) Mitochondrial DNA stress primes the antiviral innate immune response.

Jeremiah N et. al. (2014) Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations.

Zhu Q et al. (2014) Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation.

Liu Y et. al. (2014) Activated STING in a vascular and pulmonary syndrome.

Zhang L et al. (2014) NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.

You F et al. (2013) ELF4 is critical for induction of type I interferon and the host antiviral response.

Ablasser A et al. (2013) Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

Chen H et al. (2011) Activation of STAT6 by STING is critical for antiviral innate immunity.

Burdette DL et al. (2011) STING is a direct innate immune sensor of cyclic di-GMP.

Ishikawa H et al. (2009) STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity.

Sun W et al. (2009) ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization.

Li Y et al. (2009) ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response.

Zhong B et al. (2009) The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA.

Ishikawa H et al. (2008) STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.

Jin L et al. (2008) MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals.

Liu S et al. (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.

Wu J et al. (2013) Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.