Toll/interleukin-1 receptor domain-containing adapter protein
The TIRAP gene encodes a receptor for various pathogens. Mutations cause immunodeficiencies in particular a susceptibility to pneumococcal infections.
Genetests:
Related Diseases:
References:
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Kagan JC et al. (2006) Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling.
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Horng T et al. (2001) TIRAP: an adapter molecule in the Toll signaling pathway.
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Fitzgerald KA et al. (2001) Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.
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Bannerman DD et al. (2002) TIRAP mediates endotoxin-induced NF-kappaB activation and apoptosis in endothelial cells.
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Yamamoto M et al. (2002) Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.
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Horng T et al. (2002) The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors.
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Hawn TR et al. (2006) A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis.
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Khor CC et al. (2007) A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.
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Miggin SM et al. (2007) NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
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Nejentsev S et al. (2008) Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations.
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George J et al. (2010) MyD88 adaptor-like D96N is a naturally occurring loss-of-function variant of TIRAP.
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12. |
Dowling JK et al. (2019) The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses.
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Update: Aug. 14, 2020