Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
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Low affinity immunoglobulin gamma Fc region receptor II-a

The FCGR2A gene encodes a component of an immunoglobulin receptor. Mutations cause susceptibility to systemuc lupus erythematosus and various infections.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Susceptibility to lupus nephritis
FCGR2A
Susceptibility to malaria
FCGR2A
FCGR2B
TNF
Susceptibility to pseudomonas infection
FCGR2A
Susceptibility to systemic lupus erythematosus
CTLA4
DNASE1
FCGR2A
FCGR2B
PTPN22
Susceptibility to lupus nephritis
FCGR2A
Systemic lupus erythematosus susceptibility to 9
CR2
TREX1

References:

1.

Sammartino L et al. (1988) Assignment of the gene coding for human FcRII (CD32) to bands q23q24 on chromosome 1.

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2.

Schuldt K et al. (2010) FCGR2A functional genetic variant associated with susceptibility to severe malarial anaemia in Ghanaian children.

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3.

Asano K et. al. (2009) A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.

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4.

Lu J et al. (2008) Structural recognition and functional activation of FcgammaR by innate pentraxins.

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5.

Rodrigo WW et al. (2006) Differential enhancement of dengue virus immune complex infectivity mediated by signaling-competent and signaling-incompetent human Fcgamma RIA (CD64) or FcgammaRIIA (CD32).

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6.

De Rose V et al. (2005) Fcgamma receptor IIA genotype and susceptibility to P. aeruginosa infection in patients with cystic fibrosis.

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7.

Stein MP et al. (2000) C-reactive protein binding to FcgammaRIIa on human monocytes and neutrophils is allele-specific.

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8.

Moser KL et al. (1998) Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees.

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9.

Salmon JE et al. (1996) Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.

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10.

Oakey RJ et al. (1992) Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA.

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11.

Hibbs ML et al. (1988) Molecular cloning of a human immunoglobulin G Fc receptor.

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12.

None (1989) Function and heterogeneity of human Fc receptors for immunoglobulin G.

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13.

Grundy HO et al. (1989) The polymorphic Fc gamma receptor II gene maps to human chromosome 1q.

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14.

Peltz GA et al. (1989) Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG.

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15.

Hibbs ML et al. (1985) The mouse Ly-17 locus identifies a polymorphism of the Fc receptor.

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16.

Qiu WQ et al. (1990) Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination.

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17.

Lebo RV et al. (1991) Multicolor fluorescence in situ hybridization and pulsed field electrophoresis dissect CMT1B gene region.

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18.

Machado LR et al. (2012) Evolutionary history of copy-number-variable locus for the low-affinity Fcγ receptor: mutation rate, autoimmune disease, and the legacy of helminth infection.

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Update: Aug. 14, 2020
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