Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
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Small ubiquitin-related modifier 4

The SUMO4 gene encodes a regulator of ubiquitination, in particular of proteins associated with NF-kappa-B signaling. It plays therefore a significant role in inflammation and immune regulation. Genetic variants are associated with susceptibility to type 1 diabetes.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Susceptibility to type 1 diabetes 05
SUMO4

References:

1.

Bohren KM et al. (2004) A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus.

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2.

Guo D et al. (2004) A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.

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3.

Smyth DJ et al. (2005) Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes.

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4.

Qu H et al. (2005) Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes.

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5.

Park Y et al. (2005) Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes.

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Update: Aug. 14, 2020
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