serine/threonine-protein kinase mTOR
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
Genetests:
Related Diseases:
References:
1. |
Cinà DP et al. (2012) Inhibition of MTOR disrupts autophagic flux in podocytes.
|
2. |
Bar-Peled L et al. (2013) A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
|
3. |
Yang H et al. (2013) mTOR kinase structure, mechanism and regulation.
|
4. |
Robitaille AM et al. (2013) Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis.
|
5. |
Ben-Sahra I et al. (2013) Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
|
6. |
Efeyan A et al. (2013) Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.
|
7. |
Fetalvero KM et al. (2013) Defective autophagy and mTORC1 signaling in myotubularin null mice.
|
8. |
Lee JH et al. (2012) De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly.
|
9. |
Yilmaz ÖH et al. (2012) mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.
|
10. |
Thoreen CC et al. (2012) A unifying model for mTORC1-mediated regulation of mRNA translation.
|
11. |
Lamming DW et al. (2012) Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
|
12. |
Hsieh AC et al. (2012) The translational landscape of mTOR signalling steers cancer initiation and metastasis.
|
13. |
Zeng H et al. (2013) mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function.
|
14. |
Zoncu R et al. (2011) mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.
|
15. |
Yu Y et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.
|
16. |
Hsu PP et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.
|
17. |
Lucanic M et al. (2011) N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans.
|
18. |
Narita M et al. (2011) Spatial coupling of mTOR and autophagy augments secretory phenotypes.
|
19. |
Jiao Y et al. (2011) DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.
|
20. |
Sengupta S et al. (2010) mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.
|
21. |
Sathaliyawala T et al. (2010) Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling.
|
22. |
Li N et al. (2010) mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists.
|
23. |
Yu L et al. (2010) Termination of autophagy and reformation of lysosomes regulated by mTOR.
|
24. |
Dowling RJ et al. (2010) mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs.
|
25. |
Mroske C et al. (2015) Germline activating MTOR mutation arising through gonadal mosaicism in two brothers with megalencephaly and neurodevelopmental abnormalities.
|
26. |
Terenzio M et al. (2018) Locally translated mTOR controls axonal local translation in nerve injury.
|
27. |
Gu X et al. (2017) {'i': ['S'], 'content': 'SAMTOR is an -adenosylmethionine sensor for the mTORC1 pathway.'}
|
28. |
Prouteau M et al. (2017) TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity.
|
29. |
Di Malta C et al. (2017) Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth.
|
30. |
Castellano BM et al. (2017) Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.
|
31. |
Møller RS et al. (2016) Germline and somatic mutations in the gene in focal cortical dysplasia and epilepsy.
|
32. |
Moosa S et al. (2017) Smith-Kingsmore syndrome: A third family with the MTOR mutation c.5395G>A p.(Glu1799Lys) and evidence for paternal gonadal mosaicism.
|
33. |
Mirzaa GM et al. (2016) Association of MTOR Mutations With Developmental Brain Disorders, Including Megalencephaly, Focal Cortical Dysplasia, and Pigmentary Mosaicism.
|
34. |
Chantranupong L et al. (2016) The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.
|
35. |
Ben-Sahra I et al. (2016) mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.
|
36. |
Aylett CH et al. (2016) Architecture of human mTOR complex 1.
|
37. |
Heublein S et al. (2010) Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation.
|
38. |
Schweitzer LD et al. (2015) Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.
|
39. |
Nakashima M et al. (2015) Somatic Mutations in the MTOR gene cause focal cortical dysplasia type IIb.
|
40. |
Leventer RJ et al. (2015) Hemispheric cortical dysplasia secondary to a mosaic somatic mutation in MTOR.
|
41. |
Baynam G et al. (2015) A germline MTOR mutation in Aboriginal Australian siblings with intellectual disability, dysmorphism, macrocephaly, and small thoraces.
|
42. |
Lim JS et al. (2015) Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy.
|
43. |
Jewell JL et al. (2015) Metabolism. Differential regulation of mTORC1 by leucine and glutamine.
|
44. |
Wang S et al. (2015) Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
|
45. |
Rebsamen M et al. (2015) SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
|
46. |
Liang N et al. (2014) Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex.
|
47. |
Kye MJ et al. (2014) SMN regulates axonal local translation via miR-183/mTOR pathway.
|
48. |
Thedieck K et al. (2013) Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells.
|
49. |
Kim DH et al. (2002) mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
|
50. |
Gangloff YG et al. (2004) Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development.
|
51. |
Jacinto E et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
|
52. |
Hay N et al. (2004) Upstream and downstream of mTOR.
|
53. |
Scott RC et al. (2004) Role and regulation of starvation-induced autophagy in the Drosophila fat body.
|
54. |
Sarbassov DD et al. (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
|
55. |
Murakami M et al. (2004) mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells.
|
56. |
Ravikumar B et al. (2004) Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.
|
57. |
Vellai T et al. (2003) Genetics: influence of TOR kinase on lifespan in C. elegans.
|
58. |
Kwon CH et al. (2003) mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo.
|
59. |
Kim DH et al. (2003) GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.
|
60. |
Hara K et al. (2002) Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.
|
61. |
Brugarolas J et al. (2004) Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.
|
62. |
Fingar DC et al. (2002) Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E.
|
63. |
Fang Y et al. (2001) Phosphatidic acid-mediated mitogenic activation of mTOR signaling.
|
64. |
Dennis PB et al. (2001) Mammalian TOR: a homeostatic ATP sensor.
|
65. |
Castedo M et al. (2001) Human immunodeficiency virus 1 envelope glycoprotein complex-induced apoptosis involves mammalian target of rapamycin/FKBP12-rapamycin-associated protein-mediated p53 phosphorylation.
|
66. |
Onyango P et al. (1998) Molecular cloning and expression analysis of five novel genes in chromosome 1p36.
|
67. |
Lench NJ et al. (1997) The human gene encoding FKBP-rapamycin associated protein (FRAP) maps to chromosomal band 1p36.2.
|
68. |
Moore PA et al. (1996) Assignment of the human FKBP12-rapamycin-associated protein (FRAP) gene to chromosome 1p36 by fluorescence in situ hybridization.
|
69. |
Brown EJ et al. (1994) A mammalian protein targeted by G1-arresting rapamycin-receptor complex.
|
70. |
Sabatini DM et al. (1994) RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs.
|
71. |
Zhang Y et al. (2014) Coordinated regulation of protein synthesis and degradation by mTORC1.
|
72. |
Raab-Graham KF et al. (2006) Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites.
|
73. |
None (2008) Rapamycin and tuberous sclerosis complex: from Easter Island to epilepsy.
|
74. |
Lee JH et al. (2010) Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies.
|
75. |
Rao RR et al. (2010) The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin.
|
76. |
Harrison DE et al. (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
|
77. |
Scott KL et al. (2009) GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer.
|
78. |
Araki K et al. (2009) mTOR regulates memory CD8 T-cell differentiation.
|
79. |
Delgoffe GM et al. (2009) The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment.
|
80. |
Rosner M et al. (2009) Functional interaction of mammalian target of rapamycin complexes in regulating mammalian cell size and cell cycle.
|
81. |
DiBella LM et al. (2009) Zebrafish Tsc1 reveals functional interactions between the cilium and the TOR pathway.
|
82. |
Park KK et al. (2008) Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway.
|
83. |
Mao JH et al. (2008) FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
|
84. |
Sancak Y et al. (2008) The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
|
85. |
Rodgers JT et al. (2014) mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert).
|
86. |
Cunningham JT et al. (2007) mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex.
|
87. |
Bai X et al. (2007) Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.
|
88. |
Høyer-Hansen M et al. (2007) Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.
|
89. |
Laviano A et al. (2006) Role of leucine in regulating food intake.
|
90. |
Bernardi R et al. (2006) PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR.
|
91. |
Li H et al. (2006) Nutrient regulates Tor1 nuclear localization and association with rDNA promoter.
|
92. |
Cota D et al. (2006) Hypothalamic mTOR signaling regulates food intake.
|
93. |
Holz MK et al. (2005) mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.
|
94. |
Beuvink I et al. (2005) The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.
|
95. |
Sarbassov DD et al. (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
|
Update: Aug. 14, 2020