Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

C-type lectin domain family 6 member A

The CLEC6A gene encodes a C-type lectin protein, also known as dectin-2. It is an extracellular pathogen pattern receptor that bind alpha-mannan, a polysacharide predominantly found in fungal hyphae. Deficiencies cause severe fungal infections.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Familial candidiasis
CLEC6A
Familial candidiasis 1
Familial candidiasis 2
CARD9
Familial candidiasis 3
Familial candidiasis 4
CLEC7A
Familial candidiasis 5
IL17RA
Familial candidiasis 6
IL17F
Familial candidiasis 8
TRAF3IP2

References:

1.

Ritter M et al. (2010) Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses.

external link
2.

Schenten D et al. (2011) The control of adaptive immune responses by the innate immune system.

external link
3.

Bi L et al. (2010) CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans.

external link
4.

Kanazawa N et al. (2004) Molecular cloning of human dectin-2.

external link
5.

Flornes LM et al. (2004) Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex.

external link
6.

Gavino AC et al. (2005) Identification and expression profiling of a human C-type lectin, structurally homologous to mouse dectin-2.

external link
7.

Saijo S et al. (2010) Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans.

external link
8.

Zhu LL et al. (2013) C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection.

external link
9.

Yonekawa A et al. (2014) Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria.

external link
Update: Aug. 26, 2020
Copyright © 2005-2020 by Center for Nephrology and Metabolic Disorders, Dr. Mato Nagel, MD
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Germany, Tel.: +49-3576-287922, Fax: +49-3576-287944
Sitemap | Webmail | Disclaimer | Privacy Issues