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Center for Nephrology and Metabolic Disorders
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Cytochrome P450 1A2

The CYP2D6 gene encodes a member of the cytochrome P450 superfamily. It metabolizes many pharmaceuticals.

Interpretation

This enzyme is induced in smokers, so the metabolic rate of substances may be increased by 36-38% in smokers.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Research Method Multiplex Ligation-Dependent Probe Amplification
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Disturbances of cytochrome p450 system
CYP1A2
CYP2A6
CYP2C9
CYP2D6
CYP3A4
CYP4F2
Siponimod intolerance
CYP2C9

References:

1.

Schweikl H et al. (1993) Expression of CYP1A1 and CYP1A2 genes in human liver.

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2.

Browning SL et al. (2010) CYP1A2 is more variable than previously thought: a genomic biography of the gene behind the human drug-metabolizing enzyme.

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3.

Wooding SP et al. (2002) DNA sequence variation in a 3.7-kb noncoding sequence 5' of the CYP1A2 gene: implications for human population history and natural selection.

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4.

Rasmussen BB et al. (2002) The interindividual differences in the 3-demthylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors.

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5.

Christiansen L et al. (2000) Association between CYP1A2 polymorphism and susceptibility to porphyria cutanea tarda.

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6.

Tantcheva-Poór I et al. (1999) Estimation of cytochrome P-450 CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test.

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7.

Sachse C et al. (1999) Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine.

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8.

Nakajima M et al. (1999) Genetic polymorphism in the 5'-flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans.

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9.

Buters JT et al. (1996) Role of CYP1A2 in caffeine pharmacokinetics and metabolism: studies using mice deficient in CYP1A2.

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10.

Liang HC et al. (1996) Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism.

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11.

Paolini M et al. (1999) Co-carcinogenic effect of beta-carotene.

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12.

Shimada T et al. (1994) Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

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13.

Devonshire HW et al. (1983) The contribution of genetically determined oxidation status to inter-individual variation in phenacetin disposition.

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14.

None (1967) Acetophenetidin sensitivity.

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15.

Guengerich FP et al. (1986) Human-liver cytochromes P-450 involved in polymorphisms of drug oxidation.

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16.

Sesardic D et al. (1988) A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking.

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17.

Butler MA et al. (1989) Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

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18.

Ikeya K et al. (1989) Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.

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19.

Vistisen K et al. (1992) Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine.

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Update: Aug. 26, 2020
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