Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Highly sensitive PNA-based PCR

Name

Highly sensitive PNA-based PCR

Test Details

PNA-PCR is a highly sensitive PCR by which the amplification of the normal sequence is suppressed by PNA binding, so only mutated alleles are amplified in significant quantities. This is of particular importance to detect rare somatic mutations present as mosaic.

Specificity

A single mutated allele can be detected in 1000-5000 normal alleles.

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