Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Heterotopic Ossification

Heterotopic Ossification is the formation of bone like tissues outside the skeleton, predominantly in connective tissues.


Albright hereditary osteodystrophy
In Albright hereditary osteodystrophy (AHO) subcutaneous ossifications are accompanied by hormone resistance and dysmorphic features.
Fibrodysplasia ossificans progressiva
In fibrodysplasia Ossificans Progressiva (FOP) heterotopic bone formation is localized in tendons, ligaments, skeletal muscles and fascia. Before the appearance of bone like tissues tumor-like inflammation (“flare-ups”) is observed.
Progressive osseous heteroplasia
With progressive osseous heteroplasia ossification starts in childhood with superficial dermal ossification.
Update: April 29, 2019