ZBP1-Gen
Das ZBP1-Gen kodiert ein Protein welches bei der angeborenen Immunität beteiligt ist. Es erkennt fremde DNA in der Zelle.
Gentests:
Klinisch |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Schwartz T et al. (1999) Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA.
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2. |
Fu Y et al. (1999) Cloning of DLM-1, a novel gene that is up-regulated in activated macrophages, using RNA differential display.
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3. |
Rothenburg S et al. (2002) Complex regulation of the human gene for the Z-DNA binding protein DLM-1.
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4. |
Takaoka A et al. (2007) DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.
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5. |
Wang R et al. (2020) Gut stem cell necroptosis by genome instability triggers bowel inflammation.
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6. |
Jiao H et al. (2020) Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation.
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Update: 23. Juni 2025