Cytochrom P450 1A1
Das CYP1A1-Gen kodiert ein Enzym der Cytochrom P450-Familie. Diese Enzyme sind für den Medikamentenstoffwechsel und die Synthese von Lipiden und Steoidhormonen verantwortlich. Sie befinden sich auf dem endoplasmatischen Retikulum.
Gentests:
Klinisch |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Jaiswal AK et al. (1987) Comparison of human mouse P1450 upstream regulatory sequences in liver- and nonliver-derived cell lines.
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2. |
None (1997) Environment and cancer: who are susceptible?
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3. |
Mooney LA et al. (1997) Contribution of genetic and nutritional factors to DNA damage in heavy smokers.
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4. |
Xu X et al. (1996) Cytochrome P450 CYP1A1 MspI polymorphism and lung cancer susceptibility.
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5. |
Kawajiri K et al. (1996) Association of CYP1A1 germ line polymorphisms with mutations of the p53 gene in lung cancer.
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6. |
Wiebel FJ et al. (1981) Expression of aromatic polycyclic hydrocarbon-induced monooxygenase (aryl hydrocarbon hydroxylase) in man x mouse hybrids is associated with human chromosome 2.
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7. |
Tukey RH et al. (1984) Localization of cytochrome P1-450 and P3-450 genes to mouse chromosome 9.
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8. |
Gorman C et al. (1983) High efficiency DNA-mediated transformation of primate cells.
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9. |
Kouri RE et al. (1982) Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes.
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10. |
Hildebrand CE et al. (1985) Regional linkage analysis of the dioxin-inducible P-450 gene family on mouse chromosome 9.
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11. |
Hildebrand CE et al. (1985) Assignment of the human 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 gene to chromosome 15.
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12. |
Ocraft KP et al. (1985) Localization of the human aryl hydrocarbon hydroxylase gene to the 2q31----2pter region of chromosome 2.
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13. |
Jaiswal AK et al. (1985) Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence.
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14. |
Jaiswal AK et al. (1986) Human P3(450): cDNA and complete amino acid sequence.
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15. |
Jaiswal AK et al. (1986) Two RFLPs associated with the human P1450 gene linked to the MPI locus on chromosome 15 [HGM8 D15S8].
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16. |
Paolini M et al. (1999) Co-carcinogenic effect of beta-carotene.
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17. |
Nebert DW et al. (1987) P450 genes: structure, evolution, and regulation.
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18. |
Kawajiri K et al. (1986) Structure and drug inducibility of the human cytochrome P-450c gene.
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19. |
Quattrochi LC et al. (1985) Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6.
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20. |
Jaiswal AK et al. (1985) Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism.
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21. |
Schiering C et al. (2017) Feedback control of AHR signalling regulates intestinal immunity.
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22. |
Jones SN et al. (1991) Induction of the Cyp1a-1 dioxin-responsive enhancer in transgenic mice.
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23. |
Petersen DD et al. (1991) Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP.
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24. |
Kawajiri K et al. (1990) Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P450IA1 gene.
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25. |
Nakachi K et al. (1991) Genetic susceptibility to squamous cell carcinoma of the lung in relation to cigarette smoking dose.
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26. |
Jiang Z et al. (2005) Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.
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27. |
Wang X et al. (2002) Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight.
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28. |
Corchero J et al. (2001) Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation.
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29. |
Thum T et al. (2000) Gene expression in distinct regions of the heart.
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30. |
Brown S et al. (1976) Assignment of a locus required for flavoprotein-linked monooxygenase expression to human chromosome 2.
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Update: 23. Juni 2025