Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
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Glutathion S-Transferase Mu 1

Gentests:

Klinisch Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25 Tage
Probentyp genomische DNS
Klinisch Untersuchungsmethoden Multiplex ligationsabhängige Amplifikation
Bearbeitungszeit 25 Tage
Probentyp genomische DNS

Verknüpfte Erkrankungen:

Referenzen:

1.

Strange RC et al. (1984) The human glutathione S-transferases: studies on the tissue distribution and genetic variation of the GST1, GST2 and GST3 isozymes.

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2.

Seidegård J et al. (1990) Isoenzyme(s) of glutathione transferase (class Mu) as a marker for the susceptibility to lung cancer: a follow up study.

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3.

Suzuki T et al. (1987) Electrophoretic and immunological analysis of human glutathione S-transferase isozymes.

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4.

Seidegård J et al. (1988) Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion.

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5.

DeJong JL et al. (1988) The human liver glutathione S-transferase gene superfamily: expression and chromosome mapping of an Hb subunit cDNA.

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6.

Harada S et al. (1987) Liver glutathione S-transferase polymorphism in Japanese and its pharmacogenetic importance.

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7.

Seidegård J et al. (1986) A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancer.

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8.

None (1985) The isoenzymes of glutathione transferase.

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9.

Strange RC et al. (1985) The human glutathione S-transferases: developmental aspects of the GST1, GST2, and GST3 loci.

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10.

Board P et al. (1990) Genetic heterogeneity of the human glutathione transferases: a complex of gene families.

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11.

Scott EM et al. (1980) Variability of glutathione S-transferase of human erythrocytes.

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12.

Trizna Z et al. (1995) Glutathione s-transferase genotypes as risk factors for head and neck cancer.

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13.

Pearson WR et al. (1993) Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome 1p13.

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14.

Zhong S et al. (1993) Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer.

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15.

None (1996) Chemoprevention of lung cancer by isothiocyanates.

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16.

Chen CL et al. (1996) Simultaneous characterization of glutathione S-transferase M1 and T1 polymorphisms by polymerase chain reaction in American whites and blacks.

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17.

McLellan RA et al. (1997) Characterization of a human glutathione S-transferase mu cluster containing a duplicated GSTM1 gene that causes ultrarapid enzyme activity.

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18.

Xu S et al. (1998) Characterization of the human class Mu glutathione S-transferase gene cluster and the GSTM1 deletion.

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19.

Zhong S et al. (1992) Chromosomal assignment and linkage analysis of the human glutathione S-transferase mu gene (GSTM1) using intron specific polymerase chain reaction.

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20.

Gilliland FD et al. (2004) Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study.

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21.

Islam MQ et al. (1989) Chromosomal localization of human glutathione transferase genes of classes alpha, mu and pi.

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22.

None (1981) Biochemical genetics of glutathione-S-transferase in man.

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23.

Cotton SC et al. (2000) Glutathione S-transferase polymorphisms and colorectal cancer: a HuGE review.

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24.

Godschalk RW et al. (2001) Modulation of DNA and protein adducts in smokers by genetic polymorphisms in GSTM1,GSTT1, NAT1 and NAT2.

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25.

Lee KA et al. (2001) Increased frequencies of glutathione S-transferase (GSTM1 and GSTT1) gene deletions in Korean patients with acquired aplastic anemia.

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26.

Carless MA et al. (2002) The GSTM1 null genotype confers an increased risk for solar keratosis development in an Australian Caucasian population.

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27.

Verlaan M et al. (2003) Glutathione S-transferase Mu null genotype affords protection against alcohol induced chronic pancreatitis.

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28.

Lohmueller KE et al. (2003) Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease.

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29.

Mannervik B et al. (1992) Nomenclature for human glutathione transferases.

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30.

French D et al. (2005) Global gene expression as a function of germline genetic variation.

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31.

Brennan P et al. () Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach.

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32.

van Poppel G et al. (1992) Increased cytogenetic damage in smokers deficient in glutathione S-transferase isozyme mu.

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33.

Huang RS et al. (2009) Population-specific GSTM1 copy number variation.

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34.

DeJong JL et al. (1991) The human Hb (mu) class glutathione S-transferases are encoded by a dispersed gene family.

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35.

Strange RC et al. (1991) The human glutathione S-transferases: a case-control study of the incidence of the GST1 0 phenotype in patients with adenocarcinoma.

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Update: 23. Juni 2025
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