Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Das FGF10-Gen kodiert einen Fibroblastenwachstumsfaktor der bei der Entwicklung von Gehirns, Lunge und Extremitäten sowie bei der Wundheilung beteiligt ist. Mutationen führen zu autosomal dominanten Erkrankungen Tränen- und Speicheldrüsenaplasie und Lakrimo-aurikulo-dento-digitales Syndrom.
| Klinisch | Untersuchungsmethoden | Familienuntersuchung |
| Bearbeitungszeit | 5 Tage | |
| Probentyp | genomische DNS |
| Klinisch | Untersuchungsmethoden | Hochdurchsatz-Sequenzierung |
| Bearbeitungszeit | 25 Tage | |
| Probentyp | genomische DNS |
| Forschung | Untersuchungsmethoden | Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens |
| Bearbeitungszeit | 25 Tage | |
| Probentyp | genomische DNS |
| Forschung | Untersuchungsmethoden | Multiplex ligationsabhängige Amplifikation |
| Bearbeitungszeit | 25 Tage | |
| Probentyp | genomische DNS |
| 1. |
Rice R et al. (2004) Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. 
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| 2. |
Gros J et al. (2014) Vertebrate limb bud formation is initiated by localized epithelial-to-mesenchymal transition.
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| 3. |
Frenz DA et al. (2010) Retinoid signaling in inner ear development: A "Goldilocks" phenomenon.
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| 4. |
Nechiporuk A et al. (2008) FGF-dependent mechanosensory organ patterning in zebrafish.
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| 5. |
Umemori H et al. (2004) FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain.
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| 6. |
Sakaue H et al. (2002) Requirement of fibroblast growth factor 10 in development of white adipose tissue.
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| 7. |
Bagai S et al. (2002) Fibroblast growth factor-10 is a mitogen for urothelial cells.
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| 8. |
Kelly RG et al. (2001) The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm.
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| 9. |
Suzuki K et al. (2000) Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf10 gene.
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| 10. |
None (1999) Morphogenesis.
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| 11. |
Sekine K et al. (1999) Fgf10 is essential for limb and lung formation.
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| 12. |
Min H et al. (1998) Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless.
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| 13. |
Emoto H et al. (1997) Structure and expression of human fibroblast growth factor-10.
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| 14. |
Klar J et al. (2011) Fibroblast growth factor 10 haploinsufficiency causes chronic obstructive pulmonary disease.
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| 15. |
Entesarian M et al. (2007) FGF10 missense mutations in aplasia of lacrimal and salivary glands (ALSG).
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| 16. |
Milunsky JM et al. (2006) LADD syndrome is caused by FGF10 mutations.
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| 17. |
Entesarian M et al. (2005) Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands.
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| 18. |
Watanabe Y et al. (2010) Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries.
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| 19. |
Rohmann E et al. (2006) Mutations in different components of FGF signaling in LADD syndrome.
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| 20. |
Orphanet article Orphanet ID 121794
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| 21. |
NCBI article NCBI 2255
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| 22. |
OMIM.ORG article Omim 602115
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