TIR-Domän-enthaltendes Adapterprotein 1
Das TICAM1-Gen kodiert ein Element der Signalkaskade welches von verschiedenen PPR (pathogen recognition Rezeptoren) ausgehend die Transkription von Interferon-abhängigen Genen stimuliert. Mutationen führen zu erhöhter Anfälligkeit für Herpes Encephalitis und COVID-19.
Gentests:
Klinisch |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Gavin AL et al. (2006) Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling.
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2. |
Zhang Q et al. (2020) Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.
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3. |
Meylan E et al. (2004) RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation.
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4. |
Mørk N et al. (2015) Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis.
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5. |
Liu S et al. (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
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6. |
Rathinam VA et al. (2012) TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
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7. |
Yamamoto M et al. (2002) Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.
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8. |
Oshiumi H et al. (2003) TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.
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9. |
Yamamoto M et al. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.
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10. |
Hoebe K et al. (2003) Identification of Lps2 as a key transducer of MyD88-independent TIR signalling.
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11. |
Carty M et al. (2006) The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.
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12. |
Riad A et al. (2011) TRIF is a critical survival factor in viral cardiomyopathy.
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13. |
Zhang Z et al. (2011) DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells.
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14. |
Sancho-Shimizu V et al. (2011) Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency.
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Update: 23. Juni 2025