Molekulargenetisches Labor
Zentrum für Nephrologie und Stoffwechsel
Das IRF3-Gen kodiert eine Element der Signalkaskade welches für die Induktion der Trasnkription von Interferon alpha und beta und verschiedenen weiteren interferonabhängigen Genen verantwortlich ist. Mutationen erzeugen eine autosomal dominante Anfälligkeit für Herpes-Enzephalitis und COVID-19.
| Klinisch | Untersuchungsmethoden | Familienuntersuchung |
| Bearbeitungszeit | 5 Tage | |
| Probentyp | genomische DNS |
| Forschung | Untersuchungsmethoden | Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens |
| Bearbeitungszeit | 25 Tage | |
| Probentyp | genomische DNS |
| 1. |
Escalante CR et al. (2007) Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer. 
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| 2. |
Huai W et al. (2019) KAT8 selectively inhibits antiviral immunity by acetylating IRF3.
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| 3. |
Andersen LL et al. (2015) Functional IRF3 deficiency in a patient with herpes simplex encephalitis.
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| 4. |
Liu S et al. (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
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| 5. |
Chen HW et al. (2013) The roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus.
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| 6. |
Sun L et al. (2013) Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
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| 7. |
Wu J et al. (2013) Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.
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| 8. |
Bigham AW et al. (2011) Host genetic risk factors for West Nile virus infection and disease progression.
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| 9. |
Manel N et al. (2010) A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells.
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| 10. |
Menachery VD et al. (2010) Interferon regulatory factor 3-dependent pathways are critical for control of herpes simplex virus type 1 central nervous system infection.
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| 11. |
Zhang Q et al. (2020) Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.
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| 12. |
Stetson DB et al. (2006) Recognition of cytosolic DNA activates an IRF3-dependent innate immune response.
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| 13. |
Foy E et al. (2003) Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease.
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| 14. |
Sharma S et al. (2003) Triggering the interferon antiviral response through an IKK-related pathway.
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| 15. |
Bellingham J et al. (1998) Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker.
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| 16. |
Wathelet MG et al. (1998) Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo.
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| 17. |
Weaver BK et al. (1998) Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1.
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| 18. |
Au WC et al. (1995) Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.
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| 19. |
Mørk N et al. (2015) Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis.
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| 20. |
Doyle S et al. (2002) IRF3 mediates a TLR3/TLR4-specific antiviral gene program.
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