Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The KRAS gene encodes an importent protein in signal transduction. In 17-25% of human tumor cells a somatic activating mutation can be found. These mutations make make the cell resistant to GTPase activating peptides.
| Research | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Clinic | Method | Massive parallel sequencing |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 20 days | |
| Specimen type | genomic DNA |
| Research | Method | Multiplex Ligation-Dependent Probe Amplification |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Ahrendt SA et al. (2001) Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung. 
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| 2. |
Andreyev HJ et al. (1997) K-ras mutations in patients with early colorectal cancers.
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| 3. |
NCBI article NCBI 3845
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| 4. |
OMIM.ORG article Omim 190070
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| 5. |
Orphanet article Orphanet ID 122879
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| 6. |
Wikipedia article Wikipedia EN (KRAS)
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