Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact


The IL4 gene encodes interleukin-4, a cytokine secreted by activated T lymphocytes. It plays an important role in regulation of immune processes.


Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:



Horsley V et al. (2003) IL-4 acts as a myoblast recruitment factor during mammalian muscle growth.

external link

Saltman DL et al. (1993) A physical map of 15 loci on human chromosome 5q23-q33 by two-color fluorescence in situ hybridization.

external link

Kotanides H et al. (1996) Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene.

external link

Kawashima T et al. (1998) Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families.

external link

Dickensheets HL et al. (1999) Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression.

external link

Hunt PJ et al. (2000) Cytokine gene polymorphisms in autoimmune thyroid disease.

external link

Carvalho LH et al. (2002) IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages.

external link

Inoue T et al. (2002) Contribution of the interleukin 4 gene to susceptibility to subacute sclerosing panencephalitis.

external link

Ozaki K et al. (2002) A critical role for IL-21 in regulating immunoglobulin production.

external link

Ghoreschi K et al. (2003) Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease.

external link

Messi M et al. (2003) Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes.

external link

Zavros Y et al. (2003) Treatment of Helicobacter gastritis with IL-4 requires somatostatin.

external link

Zee RY et al. (2004) Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis.

external link

Nguyen KD et al. (2011) Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis.

external link

Vijayanand P et al. (2012) Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V.

external link

Harada Y et al. (2012) The 3' enhancer CNS2 is a critical regulator of interleukin-4-mediated humoral immunity in follicular helper T cells.

external link

Reese TA et al. (2014) Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter.

external link

Osborne LC et al. (2014) Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation.

external link

Minutti CM et al. (2017) Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver.

external link

Leung DY et al. (1988) Clinical and immunologic aspects of the hyperimmunoglobulin E syndrome.

external link

Fields PE et al. (2002) Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation.

external link

Spilianakis CG et al. (2005) Interchromosomal associations between alternatively expressed loci.

external link

Sutherland GR et al. (1988) Interleukin 4 is at 5q31 and interleukin 6 is at 7p15.

external link

Smirnov DV et al. (1995) Tandem arrangement of human genes for interleukin-4 and interleukin-13: resemblance in their organization.

external link

Loots GG et al. (2000) Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons.

external link

Lacy DA et al. (2000) Faithful expression of the human 5q31 cytokine cluster in transgenic mice.

external link

Kelly-Welch AE et al. (2003) Interleukin-4 and interleukin-13 signaling connections maps.

external link

LaPorte SL et al. (2008) Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.

external link

Wu D et al. (2011) Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.

external link

Bosurgi L et al. (2017) Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells.

external link

Le Beau MM et al. (1993) Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases.

external link

Arai N et al. (1989) Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression.

external link

Takahashi M et al. (1989) Chromosomal mapping of the mouse IL-4 and human IL-5 genes.

external link

Le Beau MM et al. (1989) Interleukin-4 and interleukin-5 map to human chromosome 5 in a region encoding growth factors and receptors and are deleted in myeloid leukemias with a del(5q).

external link

Yokota T et al. (1986) Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.

external link

Eder A et al. (1988) The 5' region of the human interleukin 4 gene: structure and potential regulatory elements.

external link

Lewis DB et al. (1993) Osteoporosis induced in mice by overproduction of interleukin 4.

external link

NCBI article

NCBI 3565 external link

OMIM.ORG article

Omim 147780 external link

Wikipedia article

Wikipedia EN (Interleukin_4) external link
Update: Aug. 14, 2020
Copyright © 2005-2021 by Center for Nephrology and Metabolic Disorders, Dr. Mato Nagel, MD
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Germany, Tel.: +49-3576-287922, Fax: +49-3576-287944
Sitemap | Webmail | Disclaimer | Privacy Issues | Website Credits