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Center for Nephrology and Metabolic Disorders
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NACHT, LRR and PYD domains-containing protein 6

The NLRP6 gene encodes a protein that is involved in innate immunity. It binds viral RNA and activates inflammasomes.


Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:



Tschopp J et al. (2003) NALPs: a novel protein family involved in inflammation.

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Grenier JM et al. (2002) Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.

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Elinav E et al. (2011) NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis.

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Anand PK et al. (2012) NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens.

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Wlodarska M et al. (2014) NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion.

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Wang P et al. (2015) Nlrp6 regulates intestinal antiviral innate immunity.

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Update: Aug. 14, 2020
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