TRAF6 gene

Ea CK et al. (2004) TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6.

Wang L et al. (2020) Host-mediated ubiquitination of a mycobacterial protein suppresses immunity.

Chen HW et al. (2015) Ring finger protein 166 potentiates RNA virus-induced interferon-β production via enhancing the ubiquitination of TRAF3 and TRAF6.

Dauphinee SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling.

Zucchelli S et al. (2010) TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains.

Yang WL et al. (2009) The E3 ligase TRAF6 regulates Akt ubiquitination and activation.

Xia ZP et al. (2009) Direct activation of protein kinases by unanchored polyubiquitin chains.

Pearce EL et al. (2009) Enhancing CD8 T-cell memory by modulating fatty acid metabolism.

Bai S et al. (2008) Tumor necrosis factor receptor-associated factor 6 is an intranuclear transcriptional coactivator in osteoclasts.

Vidal C et al. (2007) Linkage to chromosome 11p12 in two Maltese families with a highly penetrant form of osteoporosis.

King CG et al. (2006) TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis.

Häcker H et al. (2006) Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6.

Bai S et al. (2005) FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.

Akiyama T et al. (2005) Dependence of self-tolerance on TRAF6-directed development of thymic stroma.

Takayanagi H et al. (2000) T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma.

Wooff J et al. (2004) The TRAF6 RING finger domain mediates physical interaction with Ubc13.

Ohazama A et al. (2004) Traf6 is essential for murine tooth cusp morphogenesis.

Takatsuna H et al. (2003) Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling.

Ye H et al. (2002) Distinct molecular mechanism for initiating TRAF6 signalling.

Naito A et al. (2002) TRAF6-deficient mice display hypohidrotic ectodermal dysplasia.

Wang C et al. (2001) TAK1 is a ubiquitin-dependent kinase of MKK and IKK.

Deng L et al. (2000) Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain.

Wong BR et al. (1999) TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src.

Lomaga MA et al. (1999) TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.

Cao Z et al. (1996) TRAF6 is a signal transducer for interleukin-1.

West AP et al. (2011) TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.

Gautheron J et al. (2010) Identification of a new NEMO/TRAF6 interface affected in incontinentia pigmenti pathology.

Shembade N et al. (2010) Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes.