Renal insufficiency

Chronic renal failure is develops based on progressive renal damage that results in reduction of the glomerular filtration rate. At its final stage, requires renal replacement therapy (dialysis or transplantation).

Diseases

Apparent mineralocorticoid excess
	Protracted hyperkalemia and nephrocalcinosis lead to chronic renal failure.
Cystinosis
	95% of patient with cystinosis develop renal failure. It starts with 8-12 years of age.
Dent disease
	Up to 80% of male patients reach end-stage renal failure in their 30-50th decade. Cause is progressive nephrocalcinosis and complications of recurrent nephrolithiasis.
ATTR amyloidosis
	Though renal insufficiency may develop due to renal involvement, this condition will rarely dominate the clinical picture.