Plasminogen
Das PLG-Gen kodiert Plasminogen ein Zymogen, welches wenn aktiviert die Auflösung von Fibrin-Thromben bewirkt. Mutationen führen zu autosomal rezessivem Plasminogen-Mangel und Conjunctivitis lignosa. Das bei der Aktivierung abgetrennte Spaltprodukt besitzt eine angiostatische Wirkung. Erkrankungen, die diesen Teil des Proteins betreffen, sind bisher noch nicht bekannt.
Gentests:
Klinisch |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Gately S et al. (1996) Human prostate carcinoma cells express enzymatic activity that converts human plasminogen to the angiogenesis inhibitor, angiostatin.
|
2. |
Miyata T et al. (1984) Plasminogens Tochigi II and Nagoya: two additional molecular defects with Ala-600----Thr replacement found in plasmin light chain variants.
|
3. |
Sakata Y et al. (1980) Molecular abnormality of plasminogen.
|
4. |
Eiberg H et al. (1984) Linkage of plasma alpha-L-fucosidase (FUCA2) and the plasminogen (PLG) system.
|
5. |
Bissbort S et al. (1983) Genetic linkage relations of the human plasminogen gene.
|
6. |
Nakamura S et al. (1982) Genetic polymorphism of human plasminogen in the Japanese population: new plasminogen variants and relationship between plasminogen phenotypes and their biological activities.
|
7. |
Ikemoto S et al. (1982) Genetic polymorphism of human plasminogen in a Japanese population.
|
8. |
Kazama M et al. () Abnormal plasminogen, a case of recurrent thrombosis.
|
9. |
Raum D et al. (1980) Genetic polymorphism of human plasminogen.
|
10. |
Magnaghi P et al. (1995) A recombination event in the closely linked plasminogen and apolipoprotein(a) gene loci.
|
11. |
Ploplis VA et al. (1995) Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice.
|
12. |
Bugge TH et al. (1995) Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.
|
13. |
Rao PH et al. (1994) Subregional mapping of 8 single copy loci to chromosome 6 by fluorescence in situ hybridization.
|
14. |
Patrassi GM et al. (1993) Unusual thrombotic-like retinopathy (Coats' disease) associated with congenital plasminogen deficiency type I.
|
15. |
Azuma H et al. (1993) Congenital plasminogen deficiency caused by a Ser572 to Pro mutation.
|
16. |
Romer J et al. (1996) Impaired wound healing in mice with a disrupted plasminogen gene.
|
17. |
Kunert A et al. (2007) Immune evasion of the human pathogen Pseudomonas aeruginosa: elongation factor Tuf is a factor H and plasminogen binding protein.
|
18. |
Cao Y et al. (1996) Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells.
|
19. |
Boyle MD et al. (1997) Plasminogen activation by invasive human pathogens.
|
20. |
Kida M et al. (1997) Characterization of the 5'-flanking regions of plasminogen-related genes A and B.
|
21. |
Murata M et al. (1997) Ala601-Thr type dysplasminogenaemia genetically diagnosed in patients with retinochoroidal vascular disorders.
|
22. |
Cao Y et al. (1998) Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases.
|
23. |
Iijima H et al. (1998) Familial dysplasminogenemia with central retinal vein and cilioretinal artery occlusion.
|
24. |
Higuchi Y et al. (1998) Plasminogen Kanagawa-I, a novel missense mutation, is caused by the amino acid substitution G732R.
|
25. |
Gebbia JA et al. (1999) The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis.
|
26. |
Fischer MB et al. (2000) Binding of disease-associated prion protein to plasminogen.
|
27. |
Drixler TA et al. (2001) Angiostatin inhibits pathological but not physiological retinal angiogenesis.
|
28. |
Swaisgood CM et al. (2002) In vivo regulation of plasminogen function by plasma carboxypeptidase B.
|
29. |
Lund LR et al. (2006) Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.
|
30. |
Nguyen TM et al. (2007) Kringle 5 of human plasminogen, an angiogenesis inhibitor, induces both autophagy and apoptotic death in endothelial cells.
|
31. |
Gong Y et al. (2008) Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice.
|
32. |
Miyata T et al. (1982) Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site.
|
33. |
O'Reilly MS et al. (1994) Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.
|
34. |
Soria J et al. (1983) Plasminogen Paris I: congenital abnormal plasminogen and its incidence in thrombosis.
|
35. |
McLean JW et al. () cDNA sequence of human apolipoprotein(a) is homologous to plasminogen.
|
36. |
Aoki N et al. (1978) Abnormal plasminogen. A hereditary molecular abnormality found in a patient with recurrent thrombosis.
|
37. |
Shigekiyo T et al. (1992) Type I congenital plasminogen deficiency is not a risk factor for thrombosis.
|
38. |
None (1990) Ligneous conjunctivitis: an ophthalmic disease with potentially fatal tracheobronchial obstruction. Laryngeal and tracheobronchial features.
|
39. |
Dolan G et al. (1988) Thrombovascular disease and familial plasminogen deficiency: a report of three kindreds.
|
40. |
Bateman JB et al. () Ligneous conjunctivitis: an autosomal recessive disorder.
|
41. |
Tait RC et al. (1996) Isolated familial plasminogen deficiency may not be a risk factor for thrombosis.
|
42. |
Schuster V et al. (1997) Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis.
|
43. |
Drew AF et al. (1998) Ligneous conjunctivitis in plasminogen-deficient mice.
|
44. |
Kao WW et al. (1998) Healing of corneal epithelial defects in plasminogen- and fibrinogen-deficient mice.
|
45. |
Schott D et al. (1998) Therapy with a purified plasminogen concentrate in an infant with ligneous conjunctivitis and homozygous plasminogen deficiency.
|
46. |
Schuster V et al. (1999) Compound-heterozygous mutations in the plasminogen gene predispose to the development of ligneous conjunctivitis.
|
47. |
Tefs K et al. (2006) Molecular and clinical spectrum of type I plasminogen deficiency: A series of 50 patients.
|
48. |
Wohl RC et al. (1982) Human plasminogen variant Chicago III.
|
49. |
Mannucci PM et al. (1986) Congenital plasminogen deficiency associated with venous thromboembolism: therapeutic trial with stanozolol.
|
50. |
Hach-Wunderle V et al. (1988) Congenital deficiency of plasminogen and its relationship to venous thrombosis.
|
51. |
Forsgren M et al. (1987) Molecular cloning and characterization of a full-length cDNA clone for human plasminogen.
|
52. |
Wu HL et al. (1987) Structure and formation of microplasmin.
|
53. |
Wu HL et al. (1987) Preparation and purification of microplasmin.
|
54. |
Scharrer IM et al. (1986) Investigation of a congenital abnormal plasminogen, Frankfurt I, and its relationship to thrombosis.
|
55. |
Murray JC et al. (1987) Linkage disequilibrium of plasminogen polymorphisms and assignment of the gene to human chromosome 6q26-6q27.
|
56. |
Petersen TE et al. (1990) Characterization of the gene for human plasminogen, a key proenzyme in the fibrinolytic system.
|
57. |
Degen SJ et al. (1990) Characterization of the cDNA coding for mouse plasminogen and localization of the gene to mouse chromosome 17.
|
58. |
Ichinose A et al. (1991) Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis.
|
59. |
Kikuchi S et al. () Plasminogen with type-I mutation is polymorphic in the Japanese population.
|
60. |
None (1979) Genetic polymorphism of human plasminogen.
|
61. |
Schuster V et al. () Ligneous conjunctivitis.
|
62. |
NCBI article
NCBI 5340
|
63. |
OMIM.ORG article
Omim 173350
|
64. |
Orphanet article
Orphanet ID 117886
|
65. |
Wikipedia Artikel
Wikipedia DE (Plasmin)
|
Update: 23. Juni 2025