Isolated dominant hypomagnesemia

Isolated dominant hypomagnesemia (IDH) is an autosomal dominant disorder of magnesium wastage. The mild hypomagnesemia occurs without other electrolyte abnormalities. A mutation in the FXYD2 gene is responsible for this disorder.

Historical Aspects

An autosomal dominant magnesium wasting disorder has been first described by Geven in 1987.[Error: Macro 'ref' doesn't exist]

Symptoms

Hypomagnesaemia
	Hypomagnesemia is the single symptom of isolated hypomagnesemia (IDH). No other solute disturbances are seen.

Systematic

Hypomagnesemia
	EGFR
	Gitelman syndrome
	Hereditary myokymia type 1
	Hypomagnesemia with hypercalciuria and nephrocalcinosis
	Hypomagnesemia with hypercalciuria and nephrocalcinosis with ocular involvement
	Hypomagnesemia with normocalciuria
	Intestinal hypomagnesemia with secondary hypocalcemia
	Isolated dominant hypomagnesemia
		FXYD2
	PPI-induced Hypomagnesemia
	Renal cysts and diabetes (RCAD)
	Renal hypomagnesemia 6
	TRPM7

References:

1.	Geven WB et al. (1987) Renal magnesium wasting in two families with autosomal dominant inheritance.

2.	OMIM.ORG article Omim 154020