Pregnancy exacerbated hypertension

A mutation of the mineralocorticoid receptor causes increased sensity for aldosterone and also progesterone. Thus women during pregnancy or administration of progesterone-containing contraceptives will develop severe hypertension. Only one mutation (p.S810L) is described so far to have this effect. Inheritance is autosomal dominant.

Systematic

Pseudohyperaldosteronism
	Apparent mineralocorticoid excess
	Liddle syndrome
	Pregnancy exacerbated hypertension
		NR3C2

References:

1.	Geller DS et al. (2000) Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy.

2.	OMIM.ORG article Omim 605115