Trehalase deficiency

Trehalase deficiency is an autosomal dominant disorder caused by mutations of the TREH gene. Gastrointestinal symptoms can manifest after the ingestion of a larger amount of young edible mushrooms. In older mushrooms trehalose is cleaved into glucose and the symptoms does not appear.

Symptoms

Diarrhea
	Diarrhea in patients with trehalase deficiency manifests after the ingestion of greater amounts of trehalase, predominantly in young mushrooms.

Systematic

Food intolerance
	Adult type lactose intolerance
	Eosinophil peroxidase deficiency
	Fructose intolerance
	Fructose malabsorption
	Fructose-1,6-bisphosphatase deficiency
	Fructosuria
	Glucose-Galactose Malabsorption
	Histamine Intolerance
	Lactase deficiency
	Lysinuric protein intolerance
	Mast cell activation syndrome
	Sitosterolemia
	Trehalase deficiency
		TREH

References:

1.	Welsh JD et al. (1978) Intestinal disaccharidase activities in relation to age, race, and mucosal damage.

2.	Murray IA et al. (2000) Intestinal trehalase activity in a UK population: establishing a normal range and the effect of disease.

3.	Gudmand-Høyer E et al. (1988) Trehalase deficiency in Greenland.

4.	OMIM.ORG article Omim 612119

5.	Orphanet article Orphanet ID 103909