The disposition of attenuated cholesterol lowering by statins is hereditary. Among others, the gene HMGCR is responsible.
| 1. |
Kathiresan S et al. (2008) Polymorphisms associated with cholesterol and risk of cardiovascular events.
|
| 2. |
Yu CY et al. (2014) HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism.
|
| 3. |
None (2004) Genetic polymorphisms and statin therapy.
|
| 4. |
Chasman DI et al. (2004) Pharmacogenetic study of statin therapy and cholesterol reduction.
|
| 5. |
Wang CY et al. (2003) Lovastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, induces apoptosis and differentiation in human anaplastic thyroid carcinoma cells.
|
| 6. |
Sever N et al. (2003) Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain.
|
| 7. |
Istvan ES et al. (2001) Structural mechanism for statin inhibition of HMG-CoA reductase.
|
| 8. |
Van Doren M et al. (1998) HMG-CoA reductase guides migrating primordial germ cells.
|
| 9. |
Reynolds GA et al. (1984) HMG CoA reductase: a negatively regulated gene with unusual promoter and 5' untranslated regions.
|
| 10. |
Osborne TF et al. (1985) 5' end of HMG CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcription.
|
| 11. |
Mohandas T et al. (1986) Assignment of human 3-hydroxy-3-methylglutaryl coenzyme A reductase gene to q13----q23 region of chromosome 5.
|
| 12. |
None (1987) Conservation of promoter sequence but not complex intron splicing pattern in human and hamster genes for 3-hydroxy-3-methylglutaryl coenzyme A reductase.
|
| 13. |
Humphries SE et al. (1985) The isolation, characterisation, and chromosomal assignment of the gene for human 3-hydroxy-3-methylglutaryl coenzyme A reductase, (HMG-CoA reductase).
|
| 14. |
Goldstein JL et al. (1990) Regulation of the mevalonate pathway.
|
| 15. |
Aulchenko YS et al. (2009) Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
|
| 17. |
Teslovich TM et al. (2010) Biological, clinical and population relevance of 95 loci for blood lipids.
|
| 18. |
OMIM.ORG article Omim 142910
|