Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Humoral hypercalcemia of malignancy

Humoral hypercalcemia of malignancy is a paraneoplastic symptom that is caused by an enhanced secretion of PTH-related protein. It is not clear yet if structural variations of the PTHLH gene influence the paraneoplastic response.

Systematic

Disorders of the parathyroid hormone system
Humoral hypercalcemia of malignancy
PTHLH
Hyperparathyroidism
Hypoparathyroidism
Parathyroid adenoma
Parathyroid carcinoma
Pseudohyperparathyreoidism
Pseudohypoparathyroidism

References:

1.

Maass PG et al. (2010) A cis-regulatory site downregulates PTHLH in translocation t(8;12)(q13;p11.2) and leads to Brachydactyly Type E.

external link
2.

Kir S et al. (2014) Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia.

external link
3.

None (2003) 10 years of mouse cancer modifier loci: human relevance.

external link
4.

Hsiao LT et al. (2002) Superior vena cava syndrome and hypercalcaemia in a patient with a primary mediastinal B-cell lymphoma secreting parathyroid hormone-related protein.

external link
5.

Bakre MM et al. (2002) Parathyroid hormone-related peptide is a naturally occurring, protein kinase A-dependent angiogenesis inhibitor.

external link
6.

Miao D et al. (2002) Parathyroid hormone is essential for normal fetal bone formation.

external link
7.

Manenti G et al. (2000) A cancer modifier role for parathyroid hormone-related protein.

external link
8.

None (2000) The physiology of parathyroid hormone-related protein.

external link
9.

Lanske B et al. (1999) Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development.

external link
10.

Philbrick WM et al. (1998) Parathyroid hormone-related protein is required for tooth eruption.

external link
11.

Wysolmerski JJ et al. (1998) Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development.

external link
12.

Henry JG et al. (1997) Parathyroid hormone-related protein-(1-36) is biologically active when administered subcutaneously to humans.

external link
13.

Vortkamp A et al. (1996) Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein.

external link
14.

Karaplis AC et al. (1994) Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.

external link
15.

Holick MF et al. (1994) A parathyroid hormone antagonist stimulates epidermal proliferation and hair growth in mice.

external link
16.

Suva LJ et al. (1987) A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression.

external link
17.

Broadus AE et al. (1988) Humoral hypercalcemia of cancer. Identification of a novel parathyroid hormone-like peptide.

external link
18.

Mangin M et al. (1989) Isolation and characterization of the human parathyroid hormone-like peptide gene.

external link
19.

Moseley JM et al. (1987) Parathyroid hormone-related protein purified from a human lung cancer cell line.

external link
20.

Mangin M et al. (1988) Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy.

external link
21.

Yasuda T et al. (1989) Characterization of the human parathyroid hormone-like peptide gene. Functional and evolutionary aspects.

external link
22.

Hammonds RG et al. (1989) Purification and characterization of recombinant human parathyroid hormone-related protein.

external link
23.

Hendy GN et al. (1990) Gene for parathyroid hormone-like peptide is on mouse chromosome 6.

external link
24.

Wysolmerski JJ et al. (2001) Absence of functional type 1 parathyroid hormone (PTH)/PTH-related protein receptors in humans is associated with abnormal breast development and tooth impaction.

external link
25.

Klopocki E et al. (2010) Deletion and point mutations of PTHLH cause brachydactyly type E.

external link
26.

Lanske B et al. (1996) PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth.

external link
27.

OMIM.ORG article

Omim 168470 external link
Update: Aug. 14, 2020
Copyright © 2005-2024 by Center for Nephrology and Metabolic Disorders, Dr. Mato Nagel, MD
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Germany, Tel.: +49-3576-287922, Fax: +49-3576-287944
Sitemap | Webmail | Disclaimer | Privacy Issues | Website Credits