Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Inherited leanness is a diagnosis made by exclusion of anorexia and lipodystrophy. It is a dominant disorder caused by mutations of the AGRP gene.
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Kitamura T et al. (2006) Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. 
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Shutter JR et al. (1997) Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.
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| 3. |
Ollmann MM et al. (1997) Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein.
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Graham M et al. (1997) Overexpression of Agrt leads to obesity in transgenic mice.
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Katsuki A et al. (2001) Plasma levels of agouti-related protein are increased in obese men.
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Brown AM et al. (2001) The gene structure and minimal promoter of the human agouti related protein.
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Argyropoulos G et al. (2002) A polymorphism in the human agouti-related protein is associated with late-onset obesity.
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| 8. |
Marks DL et al. (2004) Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans.
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| 9. |
Luquet S et al. (2005) NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates.
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| 10. |
Andrews ZB et al. (2008) UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.
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| 11. |
Atasoy D et al. (2012) Deconstruction of a neural circuit for hunger.
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| 12. |
Krashes MJ et al. (2014) An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.
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| 13. |
OMIM.ORG article Omim 602311
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