Somatic capillary infantile hemangioma is a benign red skin tumor quite often found in newborns and infants. In the tumaor cells mutations of the genes FLT4 and KDR can be found.
Capillary infantile hemangioma | ||||
Capillary infantile hemangioma | ||||
FLT4 | ||||
Capillary infantile hemangioma with germline mutation | ||||
FLT4 | ||||
1. |
Walter JW et al. (2002) Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma. |
2. |
Blei F et al. (1998) Familial segregation of hemangiomas and vascular malformations as an autosomal dominant trait. |
3. |
Walter JW et al. (1999) Genetic mapping of a novel familial form of infantile hemangioma. |
4. |
Breugem CC et al. (2002) A locus for hereditary capillary malformations mapped on chromosome 5q. |
5. |
Ritter MR et al. (2002) Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis. |
6. |
Waner M et al. (2003) The nonrandom distribution of facial hemangiomas. |
7. |
Spring MA et al. (2005) Cutaneous vascular lesions. |
8. |
Pramanik K et al. (2009) Dusp-5 and Snrk-1 coordinately function during vascular development and disease. |
9. |
Jinnin M et al. (2008) Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. |
10. |
OMIM.ORG article Omim 602089 |