Wilms tumor (nephroblastoma) can be caused by somatic mutations of the genes GPC3, WT1, and BRCA2.
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Yunis JJ et al. (1980) Familial occurrence of the aniridia-Wilms tumor syndrome with deletion 11p13-14.1.
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Fearon ER et al. () Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours.
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Reeve AE et al. () Loss of a Harvey ras allele in sporadic Wilms' tumour.
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Orkin SH et al. () Development of homozygosity for chromosome 11p markers in Wilms' tumour.
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Koufos A et al. () Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour.
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de Martinville B et al. () The c-Ha-ras1, insulin and beta-globin loci map outside the deletion associated with aniridia-Wilms' tumour.
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Huerre C et al. () c-Ha-ras1 is not deleted in aniridia-Wilms' tumour association.
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Kaneko Y et al. (1981) Interstitial deletion of short arm of chromosome 11 limited to Wilms' tumor cells in a patient without aniridia.
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None (1981) Genetics of Wilms' tumor.
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Knudson AG et al. (1972) Mutation and cancer: a model for Wilms' tumor of the kidney.
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Brown WT et al. (1972) Wilms' tumor in three successive generations.
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Patek CE et al. (1999) A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome.
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Royer-Pokora B et al. (2010) Wilms tumor cells with WT1 mutations have characteristic features of mesenchymal stem cells and express molecular markers of paraxial mesoderm.
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Slade I et al. (2010) Constitutional translocation breakpoint mapping by genome-wide paired-end sequencing identifies HACE1 as a putative Wilms tumour susceptibility gene.
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Regev M et al. (2008) Vertical transmission of a mutation in exon 1 of the WT1 gene: lessons for genetic counseling.
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Reid S et al. (2005) Biallelic BRCA2 mutations are associated with multiple malignancies in childhood including familial Wilms tumour.
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None (1957) A Wilms' tumour family.
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Lu YJ et al. (2002) Chromosome 1q expression profiling and relapse in Wilms' tumour.
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DiGeorge AM et al. (1966) The association of aniridia, Wilms' tumor, and genital abnormalities.
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None (1998) Nephrogenic rests and the pathogenesis of Wilms tumor: developmental and clinical considerations.
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McDonald JM et al. (1998) Linkage of familial Wilms' tumor predisposition to chromosome 19 and a two-locus model for the etiology of familial tumors.
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Miyagawa K et al. (1998) Loss of WT1 function leads to ectopic myogenesis in Wilms' tumour.
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Schumacher V et al. (1997) Correlation of germ-line mutations and two-hit inactivation of the WT1 gene with Wilms tumors of stromal-predominant histology.
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| 42. |
Rahman N et al. (1996) Evidence for a familial Wilms' tumour gene (FWT1) on chromosome 17q12-q21.
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Tsuchida Y et al. (1995) [Hereditary renal tumors: Wilms' tumor--congenital anomalies' syndrome].
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Park S et al. (1993) Altered trans-activational properties of a mutated WT1 gene product in a WAGR-associated Wilms' tumor.
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| 45. |
Park S et al. (1993) Inactivation of WT1 in nephrogenic rests, genetic precursors to Wilms' tumour.
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Haber DA et al. (1993) WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant.
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| 47. |
Varanasi R et al. (1994) Fine structure analysis of the WT1 gene in sporadic Wilms tumors.
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| 48. |
Haber DA et al. (1992) A dominant mutation in the Wilms tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells.
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White GR et al. (2002) Somatic glypican 3 (GPC3) mutations in Wilms' tumour.
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Kozman HM et al. (1989) Molecular genetic evidence for common pathogenesis of childhood and adult Wilms' tumor.
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Kumar S et al. (1987) A cell line from Wilms' tumour with deletion in short arm of chromosome II.
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Haber DA et al. (1990) An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor.
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None (1990) Molecular genetics. A gene for Wilms tumour?
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van Heyningen V et al. (1990) Role for the Wilms tumor gene in genital development?
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| 55. |
Jeanpierre C et al. (1990) Constitutional and somatic deletions of two different regions of maternal chromosome 11 in Wilms tumor.
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| 56. |
Huff V et al. (1990) Parental origin of de novo constitutional deletions of chromosomal band 11p13.
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| 57. |
Schwartz CE et al. (1991) Familial predisposition to Wilms tumor does not segregate with the WT1 gene.
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| 58. |
Kakati S et al. (1991) Constitutional extra chromosomal element in a family with Wilms' tumor.
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| 59. |
Ton CC et al. (1991) Smallest region of overlap in Wilms tumor deletions uniquely implicates an 11p13 zinc finger gene as the disease locus.
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| 60. |
de Ronde A et al. (1988) Morphological transformation by early region human polyomavirus BK DNA of human fibroblasts with deletions in the short arm of one chromosome 11.
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| 61. |
Dressler GR et al. (1992) Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor.
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Blanchet P et al. (1977) XY gonadal dysgenesis with gonadoblastoma discovered after kidney transplantation.
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Francke U et al. (1979) Aniridia-Wilms' tumor association: evidence for specific deletion of 11p13.
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Knudson AG et al. (1975) Letter: Familial Wilms's tumor.
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None (1975) Bilateral Wilms' tumour. Age at diagnosis, associated congenital anormalies, and possible pattern of inheritance.
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MILLER RW et al. (1964) ASSOCIATION OF WILMS'S TUMOR WITH ANIRIDIA, HEMIHYPERTROPHY AND OTHER CONGENITAL MALFORMATIONS.
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Narahara K et al. (1984) Regional mapping of catalase and Wilms tumoraniridia, genitourinary abnormalities, and mental retardation triad loci to the chromosome segment 11p1305--p1306.
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Turleau C et al. (1984) Del11p13/nephroblastoma without aniridia.
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Rivera MN et al. (2007) An X chromosome gene, WTX, is commonly inactivated in Wilms tumor.
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van Heyningen V et al. (1985) Molecular analysis of chromosome 11 deletions in aniridia-Wilms tumor syndrome.
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None (1973) A general theory of carcinogenesis.
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None (1973) Wilms' tumour in father and son.
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Kaufman RL et al. (1973) Wilms' tumour in father and son.
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None (1986) Chromosomal deletions and enzyme deficiencies.
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Haning RV et al. (1985) A syndrome of chronic renal failure and XY gonadal dysgenesis in young phenotypic females without genital ambiguity.
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Kinberg JA et al. (1987) Nephropathy-gonadal dysgenesis, type 2: renal failure in three siblings with XY dysgenesis in one.
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Dao DD et al. (1987) Genetic mechanisms of tumor-specific loss of 11p DNA sequences in Wilms tumor.
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Weissman BE et al. (1987) Introduction of a normal human chromosome 11 into a Wilms' tumor cell line controls its tumorigenic expression.
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Seawright A et al. (1988) Analysis of WAGR deletions and related translocations with gene-specific DNA probes, using FACS-selected cell hybrids.
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Scoggin CH et al. (1985) The E7-associated cell-surface antigen: a marker for the 11p13 chromosomal deletion associated with aniridia-Wilms tumor.
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Scott J et al. () Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues.
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Reeve AE et al. () Expression of insulin-like growth factor-II transcripts in Wilms' tumour.
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| 85. |
Koufos A et al. () Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism.
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Raizis AM et al. (1985) A mitotic recombination in Wilms tumor occurs between the parathyroid hormone locus and 11p13.
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Michalopoulos EE et al. (1985) Molecular analysis of gene deletion in aniridia--Wilms tumor association.
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Schroeder WT et al. (1987) Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors.
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Mannens M et al. (1988) Molecular nature of genetic changes resulting in loss of heterozygosity of chromosome 11 in Wilms' tumours.
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Huff V et al. (1988) Lack of linkage of familial Wilms' tumour to chromosomal band 11p13.
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Grundy P et al. (1988) Familial predisposition to Wilms' tumour does not map to the short arm of chromosome 11.
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Puissant H et al. (1988) Molecular analysis of a reciprocal translocation t(5;11) (q11;p13) in a WAGR patient.
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OMIM.ORG article Omim 194070
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Wikipedia article Wikipedia EN (Wilms's_tumor)
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